946-94-1

Basic information

• Product Name: N-(4-acetylsulfanylphenyl)acetamide
• Synonyms: N-(4-acetylsulfanylphenyl)acetamide
• CAS NO: 946-94-1
• Molecular Formula: C₁₀H₁₁NO₂S
• Molecular Weight: 209.2648
• Mol File: 946-94-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 411.2°Cat760mmHg
• Flash Point: 202.5°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 5.7E-07mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: N-(4-acetylsulfanylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-acetylsulfanylphenyl)acetamide(946-94-1)
• EPA Substance Registry System: N-(4-acetylsulfanylphenyl)acetamide(946-94-1)

Safety Data

• Hazardous Substances Data: 946-94-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NO2S/c1-7(12)11-9-3-5-10(6-4-9)14-8(2)13/h3-6H,1-2H3,(H,11,12)

Upstream product

• 108-24-7 acetic anhydride 
• 1126-81-4 4-acetamidothiophenol 
• 18015-53-7 N-chloroacetyl-sulfanilyl chloride 
• 64-19-7 acetic acid 
• 100-00-5 4-chlorobenzonitrile 
• 75-36-5 acetyl chloride 
• 15119-62-7 1-acetylsulfanyl-4-nitro-benzene 
• 587-65-5 N-chloroacetyl-aniline 
• 2617-78-9 C₇H₆BrNO 
• 10387-40-3 potassium thioacetate 
• 103-88-8 4-bromoacetanilide 
• 622-50-4 4-Acetamido-1-iodobenzene 
• 1193-02-8 4-aminotiophenol 

Downstream Products

• 16766-09-9 (4-acetamidophenyl)disulfide 
• 1126-81-4 4-acetamidothiophenol 
• 64-19-7 acetic acid 
• 25006-65-9 2-(N-acetyl-sulfanilyl)-5-nitro-benzenesulfonic acid amide 
• 101513-56-8 5-amino-2-sulfanilyl-benzoic acid amide 
• 855931-99-6 acetic acid-[4-(2-methyl-4-nitro-phenylsulfanyl)-anilide] 
• 17615-73-5 5-amino-2-sulfanilyl-benzenesulfonic acid amide 
• 857953-38-9 acetic acid-[4-(4-nitro-[1]naphthylsulfanyl)-anilide] 
• 125743-96-6 4'-acetamino-2-methyl-4-nitro-diphenylsulfone 
• 857948-79-9 2-(4-acetylamino-phenylsulfanyl)-5-nitro-benzoic acid amide 
• 24573-60-2 2-(N-acetyl-sulfanilyl)-5-amino-benzenesulfonic acid amide 
• 857948-80-2 2-(N-acetyl-sulfanilyl)-5-nitro-benzoic acid amide 
• 861062-46-6 2-(4-acetylamino-phenylsulfanyl)-5-nitro-benzenesulfonic acid amide 
• 109843-23-4 N-(4-oxo-2-phenyl-4H-thiochromen-6-yl)acetamide 

Relevant articles and documents

Glucokinase activator containing nitroquinoline structure and application thereof

The invention relates to the field of medicine relevant to type II diabetes, in particular to a glucokinase activator containing a nitroquinoline structure, a preparation method of the glucokinase activator and application of the glucokinase activator to preparation of medicine for treating the type II diabetes. The structural formula of the glucokinase activator is shown in the description.

COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES

This invention provides novel compounds of formulae (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein the substituents are as defined in the specification. The present invention also relates to the novel compounds for use as a medicine, more in particular for the prevention or treatment of amyloid-related diseases, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such amyloid-related diseases. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

Efficient Cu-catalyzed base-free C-S coupling under conventional and microwave heating. A simple access to S-heterocycles and sulfides

S-aryl thioacetates can be prepared by reaction of inexpensive potassium thioacetate with both electron-rich and electron-poor aryl iodides under a base-free copper/ligand catalytic system. CuI as copper source affords S-aryl thioacetates in good to excellent yields, by using 1,10-phenanthroline as a ligand in toluene at 100°C after 24 h. Under microwave irradiation the time was drastically reduced to 2 h. Both procedures are simple and involve a low-cost catalytic system. This methodology was also applied to the "one-pot" synthesis of target heterocycles, such as 3H-benzo[c][1,2]dithiol-3-one and 2-methylbenzothiazole, alkyl aryl sulfides, diaryl disulfides and asymmetric diaryl sulfides in good yields.