1257541-93-7

Basic information

• Product Name: C₂₄H₂₈N₂O₃
• Synonyms: C₂₄H₂₈N₂O₃
• CAS NO: 1257541-93-7
• Molecular Weight: 392.498
• Mol File: 1257541-93-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₈N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₈N₂O₃(1257541-93-7)
• EPA Substance Registry System: C₂₄H₂₈N₂O₃(1257541-93-7)

Safety Data

• Hazardous Substances Data: 1257541-93-7(Hazardous Substances Data)

Upstream product

• 76-41-5 oxymorphone 
• 100-46-9 benzylamine 
• 357-07-3 oxymorphone hydrochloride 
• 73986-27-3 C₂₄H₂₆N₂O₃ 

Downstream Products

• 98634-03-8 (5α,6α)-6-amino-4,5-epoxy-3,14-dihydroxy-17-methylmorphinan 

Relevant articles and documents

Tuned-affinity bivalent ligands for the characterization of opioid receptor heteromers

Opioid receptors, including the μ- and δ-opioid receptors (MOR and DOR), are important targets for the treatment of pain. Although there is mounting evidence that these receptors form heteromers, the functional role of the MOR/DOR heteromer remains unresolved. We have designed and synthesized bivalent ligands as tools to elucidate the functional role of the MOR/DOR heteromer. Our ligands (L2 and L4) are comprised of a compound with low affinity at the DOR tethered to a compound with high affinity at the MOR, with the goal of producing ligands with "tuned affinity" at MOR/DOR heteromers as compared to DOR homomers. Here, we show that both L2 and L4 demonstrate enhanced affinity at MOR/DOR heteromers as compared to DOR homomers, thereby providing unique pharmacological tools to dissect the role of the MOR/DOR heteromer in pain.