1259224-00-4

Basic information

• Product Name: tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate
• Synonyms: tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate;tert-butyl N-[1-(4-aMinophenyl)cyclobutyl]carbaMate;[1-(4-Amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester;Carbamic acid, N-[1-(4-aminophenyl)cyclobutyl]-, 1,1-dimethylethyl ester;t-butyl (1-(4-aminophenyl)cyclobutyl)carbomate;EOS-60526;2-Methyl-2-propanyl [1-(4-aminophenyl)cyclobutyl]carbamate
• CAS NO: 1259224-00-4
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.34738
• Mol File: 1259224-00-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 416.7±34.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 12.78±0.20(Predicted)
• CAS DataBase Reference: tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate(1259224-00-4)
• EPA Substance Registry System: tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate(1259224-00-4)

Safety Data

• Hazardous Substances Data: 1259224-00-4(Hazardous Substances Data)

Usage

General Description

Tert-butyl 1-(4-aminophenyl)cyclobutylcarbamate is a chemical compound that belongs to the class of carbamate derivatives. It is a potentially hazardous substance and should be handled with care. tert-Butyl 1-(4-aMinophenyl)cyclobutylcarbaMate has various potential applications, including but not limited to pharmaceuticals, organic synthesis, and research purposes. It may also have properties that make it useful in the development of new materials or substances. However,

InChI:InChI=1S/C15H22N2O2/c1-14(2,3)19-13(18)17-15(9-4-10-15)11-5-7-12(16)8-6-11/h5-8H,4,9-10,16H2,1-3H3,(H,17,18)

Upstream product

• 140-29-4 phenylacetonitrile 
• 14377-68-5 1-phenylcyclobutanecarbonitrile 
• 1236409-69-0 1-(4-nitrophenyl)cyclobutanecarbonitrile 
• 202737-42-6 1-(4-nitrophenyl)cyclobutanecarboxylic acid 
• 1359656-25-9 tert-butyl (1-(4-nitrophenyl)cyclobutyl)carbamate 
• 1259223-99-8 4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)benzoic acid 
• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 
• 555-21-5 4-Nitrophenylacetonitrile 

Downstream Products

• 1313883-38-3 tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate 
• 1313883-39-4 tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-chloro-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate 
• 1313881-59-2 tert-butyl (1-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate 
• 1357159-36-4 tert-butyl 1-(4-(2-aminobenzamido)phenyl)cyclobutylcarbamate 
• 1416477-58-1 tert-butyl (1-{4-[(6-morpholin-4-yl-3-nitropyridin-2-yl)amino]phenyl}cyclobutyl)carbamate 
• 1416775-76-2 2-({3-[2-(2-aminopyridin-3-yl)-3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3H-imidazo[4,5-b]pyridin-5-yl]phenyl}amino)-1,1-dimethyl-2-oxoethyl acetate 
• 1416775-77-3 tert-butyl (1-{4-[2-(2-aminopyridin-3-yl)-5-{3-[(2-hydroxy-2-methylpropanoyl)amino]phenyl}-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}cyclobutyl)carbamate 
• 1416775-80-8 tert-butyl (1-{4-[2-(2-aminopyridin-3-yl)-5-{3-[(1,4-dioxan-2-ylcarbonyl)amino]phenyl}-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}cyclobutyl)carbamate 
• 1416775-82-0 tert-butyl (1-{4-[2-(2-aminopyridin-3-yl)-5-{3-[(tetrahydro-2H-pyran-4-ylcarbonyl)amino]phenyl}-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}cyclobutyl)carbamate 
• 1416775-89-7 tert-butyl (1-{4-[2-(2-aminopyridin-3-yl)-5-{3-[4-(dimethylcarbamoyl)piperidin-1-yl]phenyl}-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}cyclobutyl)carbamate 
• 1416775-88-6 tert-butyl (1-{4-[(6-{3-[4-(dimethylcarbamoyl)piperidin-1-yl]phenyl}-3-nitropyridin-2-yl)amino]phenyl}cyclobutyl)carbamate 
• 1416776-07-2 tert-Butyl (1-{4-[2-(2-aminopyridin-3-yl)-5-{3-[cis-2,6-dimethylmorpholin-4-yl]phenyl}-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}cyclobutyl)carbamate 
• 1416776-11-8 tert-butyl (1-{4-[2-(2-aminopyridin-3-yl)-5-(3-{(2R)-2-[(benzyloxy)methyl]morpholin-4-yl}phenyl)-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}cyclobutyl)carbamate 
• 1416776-12-9 tert-Butyl (1-{4-[2-(2-aminopyridin-3-yl)-5-{3-[(2R)-2-(hydroxymethyl) morpholin-4-yl]phenyl}-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}cyclobutyl)carbamate 

Relevant articles and documents

NOVEL SUBSTITUTED CYCLOBUTYLBENZENE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS

Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE

The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine: