126-11-4 Usage
Description
Tris(hydroxymethyl)nitromethane, also known as Trinitromethane, is an organic compound that serves as a versatile intermediate in various industries due to its unique chemical properties. It is an off-white to orange solid that crystallizes as white crystals in a mixed solution of ethyl acetate and benzene. It is soluble in alcohol, slightly soluble in benzene and other hydrocarbons, and has a high solubility in water at 20°C (220g/100ml). Its ability to undergo crosslinking with hexamethylene diisocyanate makes it an effective hardener for a variety of tannin-based adhesives.
Uses
Used in Organic Synthesis:
Tris(hydroxymethyl)nitromethane is used as an important raw material and intermediate in organic synthesis, contributing to the development of new compounds and materials.
Used in Pharmaceuticals:
In the pharmaceutical industry, Tris(hydroxymethyl)nitromethane is utilized as a primary and secondary intermediate, playing a crucial role in the synthesis of various drugs and medicinal compounds.
Used in Agrochemicals:
Tris(hydroxymethyl)nitromethane is employed in the agrochemical industry, where it serves as a key intermediate for the development of agricultural chemicals and pesticides.
Used in Dyestuff:
In the dyestuff industry, Tris(hydroxymethyl)nitromethane is used as an intermediate for the production of various dyes and pigments.
Used in Adhesives:
Tris(hydroxymethyl)nitromethane is an effective hardener for a variety of tannin-based adhesives, enhancing their performance and durability.
Used in Cooling Fluids and Paper and Pulp Industry:
Tris(hydroxymethyl)nitromethane is used as a bactericide and slimicide in cooling fluids and the paper and pulp industry, helping to maintain the cleanliness and efficiency of these systems.
Used in Adhesives as a Curing Agent:
As a curing agent for certain adhesives, Tris(hydroxymethyl)nitromethane improves the bonding strength and durability of the final product.
Used in Cosmetics as a Viscosity Control Agent:
In the cosmetics industry, Tris(hydroxymethyl)nitromethane is used as a viscosity controlling agent, ensuring the desired consistency and texture of various cosmetic products.
Used in Inhibiting Bacterial Growth:
Tris(hydroxymethyl)nitromethane is employed to inhibit bacterial growth in circulating industrial water systems, cutting oils, nonprotein glues, and sizings, preventing the formation of biofilms and maintaining the efficiency of these systems.
Preparation
Tris(hydroxymethyl)nitromethane is prepared by the condensation of nitromethane and formaldehyde under basic conditions.
Purification Methods
Crystallise it from CHCl3/ethyl acetate or ethyl acetate/*benzene. It is an acid and a 0.1M solution in H2O has pH 4.5. IRRITANT. [Beilstein 1 H 520.]
Check Digit Verification of cas no
The CAS Registry Mumber 126-11-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 6 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 126-11:
(5*1)+(4*2)+(3*6)+(2*1)+(1*1)=34
34 % 10 = 4
So 126-11-4 is a valid CAS Registry Number.
InChI:InChI=1/C4H9NO5/c6-1-4(2-7,3-8)5(9)10/h6-8H,1-3H2
126-11-4Relevant articles and documents
Formation and Out-of-Equilibrium, High/Low State Switching of a Nitroaldol Dynamer in Neutral Aqueous Media
Elofsson, Ulla,Karalius, Antanas,Kravchenko, Oleksandr,Ramstr?m, Olof,Szabó, Zoltán,Yan, Mingdi,Zhang, Yang
, p. 3434 - 3438 (2020)
The nitroaldol reaction is demonstrated as an efficient dynamic covalent reaction in phosphate buffers at neutral pH. Rapid equilibration was recorded with pyridine-based aldehydes, and dynamic oligomerization could be achieved, leading to nitroaldol dynamers of up to 17 repeating units. The dynamers were applied in a coherent stimuli-responsive molecular system in which larger dynamers transiently existed out-of-equilibrium in a neutral aqueous system rich in formaldehyde, controlled by nitromethane.
IS 1,3-DIHYDROXYPROPANENITRONIC ACID REALLY STABLE?
Eremenko, L. T.,Oreshko, G. V.,Lagodzinskaya, G. V.,Zabrodin, V. A.
, p. 555 - 557 (1990)
The condensation of nitromethane with paraformaldehyde in the presence of catalytic amounts of KF and tetra-n-butylammonium bromide in a medium of isopropanol does not afford stable 1,3-dihydroxypropanenitronic acid.In the neutralization of 2-nitro-1,3-propanediol sodium salt by anhydrous CF3COOH, 2-nitro-1,3-propanediol and 2-nitro-1-propen-3-ol were identified.
PROCESS FOR THE PREPARATION OF NITROALCOHOLS
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Paragraph 0018, (2013/09/26)
A process of preparing a nitroalcohol, e.g., 2-nitro-2-methyl-1-propane, from a nitropolyol, e.g., 2-nitro-2 -methyl-1,3-propanediol, the process comprising the step of contacting under hydrogenation conditions the nitropolyol with hydrogen, a hydrogenation catalyst and, optionally, a chelating agent.