1260216-16-7

Basic information

• Product Name: 7-(3',4,4',5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine
• Synonyms: 7-(3',4,4',5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine
• CAS NO: 1260216-16-7
• Molecular Weight: 395.499
• Mol File: 1260216-16-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-(3',4,4',5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(3',4,4',5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine(1260216-16-7)
• EPA Substance Registry System: 7-(3',4,4',5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine(1260216-16-7)

Safety Data

• Hazardous Substances Data: 1260216-16-7(Hazardous Substances Data)

Upstream product

• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 118758-56-8 tert-butyl 2-(2-ethoxy-2-oxoethyl)pyrrolidine-1-carboxylate 
• 89978-46-1 4-bromo-5-iodoveratrole 
• 1314910-46-7 C₈H₁₁NO 
• 1260216-07-6 1,2,3,5,8,8a-hexahydroindolizin-7-yl trifluoromethanesulfonate 
• 221664-16-0 2-bromo-3',4,4′,5-tetramethoxy-1,1'-biphenyl 
• 905717-01-3 tert-butyl 2-(2-oxobut-3-yn-1-yl)pyrrolidine-1-carboxylate 
• 443797-18-0 tert-butyl 2-(2-(methoxy(methyl)amino)-2-oxoethyl)pyrrolidine-1-carboxylate 
• 905717-35-3 2,3,8,8a-tetrahydroindolizin-7(1H)-one 

Relevant articles and documents

Modular Syntheses of Phenanthroindolizidine Natural Products

A highly concise strategy for the total synthesis of phenanthroindolizidines was developed. The one-pot iterative Suzuki-Miyaura reaction of aryl boronic acids with ortho-bromoaryl N-methyliminodiacetate (MIDA) boronate followed by a second Suzuki-Miyaura reaction with a suitable pyridyl bromide provided ortho-aza-terphenyls. Subsequent saturation of the triple bond, treatment with mesyl chloride, and reduction of the resulting dihydroindolizidinium ring afforded the hexahydroindolizines. A final vanadium-catalyzed oxidative electrocyclization provided the desired alkaloids in only three column-separation operations.