1260224-93-8

Basic information

• Product Name: 4-chloro-3'-((2-cyclohexyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid
• Synonyms: 4-chloro-3'-((2-cyclohexyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid
• CAS NO: 1260224-93-8
• Molecular Weight: 475.972
• Mol File: 1260224-93-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-3'-((2-cyclohexyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-3'-((2-cyclohexyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid(1260224-93-8)
• EPA Substance Registry System: 4-chloro-3'-((2-cyclohexyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid(1260224-93-8)

Safety Data

• Hazardous Substances Data: 1260224-93-8(Hazardous Substances Data)

Upstream product

• 19094-56-5 2-chloro-5-iodobenzoic acid 
• 610-35-5 4-hydroxyphthalic acid 
• 3975-51-7 2-cyclohexyl-5-hydroxyisoindoline-1,3-dione 
• 27550-59-0 4-hydroxyphthalic anhydride 
• 1260225-45-3 methyl 4-chloro-3'-methylbiphenyl-3-carboxylate 
• 1183393-79-4 4-chloro-3'-methylbiphenyl-3-carboxylic acid 
• 1260225-04-4 C₂₉H₂₈ClNO₄ 

Relevant articles and documents

Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats

The modification of 3′-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3- dihydro-1H-inden-5-yloxy)methyl)biphenyl-4-carboxylic acid (BINA, 1) by incorporating heteroatoms into the structure and replacing the cyclopentyl moiety led to the development of new mGluR2 positive allosteric modulators (PAMs) with optimized potency and superior druglike properties. These analogues are more potent than 1 in vitro and are highly selective for mGluR2 vs other mGluR subtypes. They have significantly improved pharmacokinetic (PK) properties, with excellent oral bioavailability and brain penetration. The benzisothiazol-3-one derivative 14 decreased cocaine self-administration in rats, providing proof-of-concept for the use of mGluR2 PAMs for the treatment of cocaine dependence.