3975-51-7

Basic information

• Product Name: 2-cyclohexyl-5-hydroxyisoindoline-1,3-dione
• Synonyms: 2-cyclohexyl-5-hydroxyisoindoline-1,3-dione
• CAS NO: 3975-51-7
• Molecular Weight: 245.278
• Mol File: 3975-51-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-cyclohexyl-5-hydroxyisoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyclohexyl-5-hydroxyisoindoline-1,3-dione(3975-51-7)
• EPA Substance Registry System: 2-cyclohexyl-5-hydroxyisoindoline-1,3-dione(3975-51-7)

Safety Data

• Hazardous Substances Data: 3975-51-7(Hazardous Substances Data)

Upstream product

• 27550-59-0 4-hydroxyphthalic anhydride 
• 108-91-8 cyclohexylamine 
• 610-35-5 4-hydroxyphthalic acid 
• 4998-76-9 cyclohexylamine hydrochloride 
• 50727-06-5 5-hydroxy-isoindole-1,3-dione 

Downstream Products

• 109803-89-6 4-(2-Cyclohexyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yloxy)-butyric acid ethyl ester 
• 1242154-45-5 2-cyclohexylisoindole-1,3-dion-5-yl (E)-3-(4-nitrophenyl)acrylate 
• 153144-28-6 2-cyclohexyl-5-hydroxyisoindolin-1-one 
• 1260224-93-8 4-chloro-3'-((2-cyclohexyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid 
• 1260225-04-4 C₂₉H₂₈ClNO₄ 
• 109803-90-9 (2-Cyclohexyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yloxy)-acetic acid ethyl ester 
• 109804-21-9 4-(2-Cyclohexyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yloxy)-butyric acid 
• 109804-22-0 (2-Cyclohexyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yloxy)-acetic acid 

Relevant articles and documents

Efficient conversion of acids and esters to amides and transamidation of primary amides using OSU-6

OSU-6, an MCM-41 type hexagonal mesoporous silica with strong Bronsted acid properties, has been used to promote the high-yield conversion of carboxylic acids and esters to carboxamides as well as transamidations of primary amides in a one-pot solventless approach. A metal-free heterogeneous catalyst that promotes all of these processes has not been previously reported. OSU-6 enables these transformations to proceed in shorter times and at lower temperatures for a broad range of substrates. An added benefit is that the catalyst can be recycled and reused multiple times without significant loss of activity.

Development of tryptase inhibitors derived from thalidomide

A novel series of tryptase inhibitors with a N-phenylphthalimide skeleton structurally derived from thalidomide (1) has been developed. Structure-activity relationship studies led to a potent and selective tryptase inhibitor, 2-(4-cyanophenyl)isoindole-1,3-dione-5-yl 3-(2-aminopyridin-5-yl)propanoate (7), with the IC50 value of 78 nM.