1260674-57-4

Basic information

• Product Name: (3-aminopyridin-4-yl)(3,4-dimethoxylphenyl)methanone
• Synonyms: (3-aminopyridin-4-yl)(3,4-dimethoxylphenyl)methanone
• CAS NO: 1260674-57-4
• Molecular Weight: 258.277
• Mol File: 1260674-57-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3-aminopyridin-4-yl)(3,4-dimethoxylphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3-aminopyridin-4-yl)(3,4-dimethoxylphenyl)methanone(1260674-57-4)
• EPA Substance Registry System: (3-aminopyridin-4-yl)(3,4-dimethoxylphenyl)methanone(1260674-57-4)

Safety Data

• Hazardous Substances Data: 1260674-57-4(Hazardous Substances Data)

Upstream product

• 155586-38-2 N,3,4-trimethoxy-N-methylbenzamide 
• 78790-79-1 3-amino-4-cyano-pyridine 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 1373775-14-4 N-[4-(3,4-dimethoxybenzoyl)pyridin-3-yl]-2,2-dimethylpropanamide 

Downstream Products

• 1373774-87-8 4-[1-(3,4-dimethoxyphenyl)ethenyl]pyridin-3-amine 
• 1373774-89-0 4-[(1E)-1-(3,4-dimethoxyphenyl)but-1-en-1-yl]pyridin-3-amine 
• 1373774-88-9 4-[(1E)-1-(3,4-dimethoxyphenyl)prop-1-en-1-yl]pyridin-3-amine 
• 1373774-95-8 N-{4-[1-(3,4-dimethoxyphenyl)ethenyl]pyridin-3-yl}formamide 
• 1373774-96-9 N-{4-[(1E)-1-(3,4-dimethoxyphenyl)prop-1-en-1-yl]pyridin-3-yl}formamide 
• 1373774-97-0 N-{4-[(1E)-1-(3,4-dimethoxyphenyl)but-1-en-1-yl]pyridin-3-yl}formamide 
• 1373775-03-1 4-[1-(3,4-dimethoxyphenyl)ethenyl]-3-isocyanopyridine 
• 1373775-04-2 4-[(1E)-1-(3,4-dimethoxyphenyl)prop-1-en-1-yl]-3-isocyanopyridine 
• 1373775-05-3 4-[(1E)-1-(3,4-dimethoxyphenyl)but-1-en-1-yl]-3-isocyanopyridine 
• 1373775-11-1 4-(3,4-dimethoxyphenyl)-1,7-naphthyridine-2(1H)-thione 
• 1373775-12-2 4-(3,4-dimethoxyphenyl)-3-methyl-1,7-naphthyridine-2(1H)-thione 
• 1373775-13-3 4-(3,4-dimethoxyphenyl)-3-ethyl-1,7-naphthyridine-2(1H)-thione 
• 1373774-79-8 1-(3-aminopyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanol 
• 1373774-80-1 1-(3-aminopyridin-4-yl)-1-(3,4-dimethoxyphenyl)propan-1-ol 

Relevant articles and documents

Palladium-catalyzed direct addition of arylboronic acids to 2-aminobenzonitrile derivatives: Synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines, and 7-benzoylindoles

A palladium-catalyzed direct addition of arylboronic acids to unprotected 2-aminobenzonitriles has been developed, leading to a wide range of 2-aminobenzophenones with moderate to excellent yields. The transformation has broad scope and high functional group tolerance. Moreover, 2-oxoindoline-7-carbonitrile and indole-7-carbonitrile were applicable to this process for the construction of 7-benzoyl-2-oxoindolines and 7-benzoylindoles, respectively. Among the compounds examined, compound 4e possessed the most potent anticancer activity against H446 and HGC-27 in vitro, with IC50 values of 0.02 μmol L-1 and 0.09 μmol L-1, respectively, while compound 4a showed the best potent anticancer activity against SGC-7901 with an IC50 value of 0.01 μmol L-1. Furthermore, we also performed in silico molecular docking calculations to investigate the interaction mode and binding affinity between the examined compounds and their tubulin target. This journal is