1261794-19-7

Basic information

• Product Name: (2-Iodo-6-methylphenyl)methanol
• Synonyms: 2-Iodo-6-methylbenzyl alcohol;(2-Iodo-6-methylphenyl)methanol
• CAS NO: 1261794-19-7
• Molecular Formula: C₈H₉IO
• Molecular Weight: 248.06093
• Mol File: 1261794-19-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-Iodo-6-methylphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Iodo-6-methylphenyl)methanol(1261794-19-7)
• EPA Substance Registry System: (2-Iodo-6-methylphenyl)methanol(1261794-19-7)

Safety Data

• Hazardous Substances Data: 1261794-19-7(Hazardous Substances Data)

Usage

Description

(2-iodo-6-methylphenyl)methanol, also known as 2-Iodo-6-methylbenzyl alcohol, is an organic compound characterized by its chemical formula C8H9IO. It presents as a pale yellow to brown liquid with a faint odor.

Uses

Used in Pharmaceutical Industry:
(2-iodo-6-methylphenyl)methanol is utilized as an intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of various medications.
Used in Agrochemical Industry:
(2-iodo-6-methylphenyl)methanol also serves as an intermediate in the production of agrochemicals, contributing to the creation of substances that help in the management and protection of crops.
Used in Organic Synthesis:
(2-iodo-6-methylphenyl)methanol is employed as a building block and a reagent in organic synthesis, enabling the construction of a wide range of organic compounds and materials.
Used in Chemical Production:
It is used as a starting material for the preparation of various derivatives, further expanding its applications across different chemical industries.
Safety Note:
It is important to handle (2-iodo-6-methylphenyl)methanol with care due to its toxic nature and potential to cause skin and eye irritation upon contact.

Upstream product

• 103440-55-7 2-methyl-6-iodobenzoic acid methyl ester 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 
• 61940-22-5 methyl 2-methyl-6-nitrobenzoate 
• 18595-13-6 2-amino-6-methylbenzoic acid methyl ester 
• 65658-16-4 2-amino-6-methylbenzyl alcohol 
• 4389-50-8 2-amino-6-methylbenzoic acid 
• 54811-50-6 2-iodo-6-methylbenzoic acid 

Downstream Products

• 1365840-82-9 (2-ethenyl-6-methylphenyl)methanol 
• 1261481-48-4 2-(bromomethyl)-1-iodo-3-methylbenzene 
• 1573172-23-2 C₂₂H₂₂IN 
• 1573172-01-6 2-((dibenzylamino)methyl)-3-methylbenzaldehyde 
• 1573171-43-3 (E)-4-(2-((dibenzylamino)methyl)-3-methylphenyl)-1,1,1-trifluorobut-3-en-2-one 

Relevant articles and documents

METHOD FOR PRODUCING DIFLUOROMETHYLENE COMPOUND

The present invention provides a method for producing a difluoromethylene compound and an intermediate thereof, which are useful in the field of pharmaceuticals. Specifically provided is a method for producing a difluoromethylene compound, including a step of allowing a compound represented by formula (6): [wherein L1 represents a halogen atom, a cyano group, a lower alkyl group, a halo-lower alkyl group, a cycloalkyl group, a lower alkoxy group, a halo-lower alkoxy group, or a hydroxy lower alkyl group; R1 represents a lower alkyl group, a halogen atom, a halo-lower alkyl group, a cycloalkyl group, a cyano group, or a hydroxy lower alkyl group; and W represents a nitrogen atom or a methine group] to react with a compound represented by formula (7): [wherein R2 represents a lower alkyl group, a halo-lower alkyl group, a cycloalkyl group, a lower alkenyl group, or an aralkyl group; and R3 represents a chlorine atom, a bromine atom, or an iodine atom].

Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds

A highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds using a novel palladium-catalyzed tandem cyclization reaction is explored. During the reaction process, C-O, C-C and C-O bonds are sequentially formed in one pot via decarboxylative allenylpalladium formation, nucleophilic attack, arylpalladium addition and intramolecular nucleophilic attack.

DIFLUOROMETHYLENE COMPOUND

The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, the present invention relates to a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.