1263097-63-7

Basic information

• Product Name: C₁₃H₂₅O₆P
• Synonyms: C₁₃H₂₅O₆P
• CAS NO: 1263097-63-7
• Molecular Weight: 308.312
• Mol File: 1263097-63-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₂₅O₆P(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₂₅O₆P(1263097-63-7)
• EPA Substance Registry System: C₁₃H₂₅O₆P(1263097-63-7)

Safety Data

• Hazardous Substances Data: 1263097-63-7(Hazardous Substances Data)

Upstream product

• 5746-57-6 L-α-Phosphatidic acid 
• 763-10-0 geranyl diphosphate 

Relevant articles and documents

Two distinct mechanisms for TIM barrel prenyltransferases in bacteria

The reactions of two bacterial TIM barrel prenyltransferases (PTs), MoeO5 and PcrB, were explored. MoeO5, the enzyme responsible for the first step in moenomycin biosynthesis, catalyzes the transfer of farnesyl to 3-phosphoglyceric acid (3PG) to give a product containing a cis-allylic double bond. We show that this reaction involves isomerization to a nerolidyl pyrophosphate intermediate followed by bond rotation prior to attack by the nucleophile. This mechanism is unprecedented for a prenyltransferase that catalyzes an intermolecular coupling. We also show that PcrB transfers geranyl and geranylgeranyl groups to glycerol-1-phosphate (G1P), making it the first known bacterial enzyme to use G1P as a substrate. Unlike MoeO5, PcrB catalyzes prenyl transfer without isomerization to give products that retain the trans-allylic bond of the prenyl donors. The TIM barrel family of PTs is unique in including enzymes that catalyze prenyl transfer by distinctly different reaction mechanisms.