5746-57-6

Basic information

• Product Name: [S,(+)]-1-O-Phosphono-L-glycerol
• Synonyms: (+)-Glycero-1-phosphoric acid;(S)-1,2,3-Propanetriol 1-dihydrogenphosphate;[S,(+)]-1-O-Phosphono-L-glycerol;D-Glycerol 3-phosphoric acid;L-Glycerol-1-phosphate;L-α-Glycerophosphoric acid;sn-glycerol 1-phosphate;a-Acid L-form
• CAS NO: 5746-57-6
• Molecular Formula: C₃H₉O₆P
• Molecular Weight: 172.07
• Mol File: 5746-57-6.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 485.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.738±0.06 g/cm3(Predicted)
• PKA: 1.84±0.10(Predicted)
• CAS DataBase Reference: [S,(+)]-1-O-Phosphono-L-glycerol(CAS DataBase Reference)
• NIST Chemistry Reference: [S,(+)]-1-O-Phosphono-L-glycerol(5746-57-6)
• EPA Substance Registry System: [S,(+)]-1-O-Phosphono-L-glycerol(5746-57-6)

Safety Data

• Hazardous Substances Data: 5746-57-6(Hazardous Substances Data)

Usage

Description

[S,(+)]-1-O-Phosphono-L-glycerol, also known as an optically active glycerol 1-phosphate with (S)-configuration, is a compound that plays a significant role in various applications due to its unique properties. It is a derivative of glycerol, a simple polyol compound, which is widely used in the pharmaceutical and chemical industries.

Uses

1. Used in Pharmaceutical Applications:
[S,(+)]-1-O-Phosphono-L-glycerol is used as a key component in the manufacturing of certain glycerophosphates. These glycerophosphates are generally used medicinally for various purposes, such as in the treatment of certain medical conditions or as additives in pharmaceutical formulations.
2. Used in Taste Enhancement:
[S,(+)]-1-O-Phosphono-L-glycerol is also used to impart taste to solutions of glycerophosphates. This application is particularly relevant in the pharmaceutical industry, where the taste of certain medications can be improved by adding this compound to the formulation.
3. Used in Calcium Glycerophosphate Production:
[S,(+)]-1-O-Phosphono-L-glycerol is an essential component in the production of Calcium Glycerophosphate, a compound that has various applications in the medical and pharmaceutical fields. Calcium Glycerophosphate is often used as a dietary supplement, a mineral source, or as an additive in the pharmaceutical industry.

Upstream product

• 25022-72-4 allyl dihydrophosphate 
• 17181-54-3 glycerol 2-phosphate, free acid 
• 64-17-5 ethanol 
• 17966-25-5 1,2-di-O-stearoyl-rac-3-glycerophosphate 
• 453-16-7 3-fluoropropane-1,2-diol 
• 556-52-5 oxiranyl-methanol 
• 770-12-7 O-phenyl phosphorodichloridate 
• 56-81-5 glycerol 
• 96-24-2 3-monochloro-1,2-propanediol 
• 46228-53-9 phosphoric acid mono-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl) ester 
• 57-04-5 dihydroxyacetone phosphate 
• 142-10-9 DL-glyceraldehyde 3-phosphate 
• 86119-84-8 phosphoric acid 
• 7732-18-5 water 

Downstream Products

• 97525-39-8 (+/-)-2,3-Di-O,O-caproyl-glycerin-1-phosphat 
• 19698-29-4 1,2-Dipalmitoylphosphatidic acid 
• 50-00-0 formaldehyd 
• 870-55-3 phosphoric acid mono-(2-oxo-ethyl) ester 
• 17181-54-3 glycerol 2-phosphate, free acid 
• 56-81-5 glycerol 
• 30170-00-4 Dimyristoylphosphatidic acid 
• 142-10-9 DL-glyceraldehyde 3-phosphate 
• 57-04-5 dihydroxyacetone phosphate 
• 64-18-6 formic acid 
• 86119-84-8 phosphoric acid 
• 1263097-63-7 C₁₃H₂₅O₆P 
• 96-26-4 dihydroxyacetone 
• 635-78-9 resorufin 

Relevant articles and documents

One-pot enzymatic reaction sequence for the syntheses of d-glyceraldehyde 3-phosphate and l-glycerol 3-phosphate

A one-pot enzymatic reaction sequence for the synthesis of optically pure d-glyceraldehyde 3-phosphate (d-GAP) and l-glycerol 3-phosphate (sn-G3P) was designed using fructose-bisphosphate aldolase from rabbit muscle (RAMA), sn-glycerol 3-phosphate dehydrogenase (sn-G3PDH) and formate dehydrogenase from Candida boidinii (FDH). The reaction sequence significantly improves the aldol cleavage of d-fructose 1,6-bisphosphate (d-F16BP) catalyzed by RAMA and yields 100% conversion of d-F16BP by overcoming thermodynamic limitation. The degradation kinetics of d-GAP under reaction conditions was investigated and a reaction kinetics model defining the entire cascade was developed. Validation of the model shows 98.5% correlation between experimental data and numerically simulated data matrices. The evaluation of different types of reactor was performed by combining the reaction kinetics model, mass balances and kinetics of the non-enzymatic degradation of d-GAP. Batch-wise operation in a stirred tank reactor (STR) is the most convenient procedure for the one-pot enzymatic syntheses of d-GAP and sn-G3P. The separation of the two products d-GAP and sn-G3P has been achieved using polyethylenimine (PEI)-cellulose TLC.

A toothpaste additive CGP new synthetic process of the (by machine translation)

The invention relates to a toothpaste additive new synthetic process of the CGP, specifically comprising the following steps: (1) under ice bath, is added to the glycerin in the POCl3 And catalyst, natural recovery to room temperature, stirring the reaction 5 - 6 h after, adds full and sodium bicarbonate solution adjusted to pH 8.0 - 9.0 after, adding calcium chloride, stirring at room temperature the reaction 10 - 12 hours, filter, collecting the filtrate; (2) to the step (1) of the filtrate obtained in adding anhydrous ethanol, stirring 0.5 - 1.0 h after, filtering, deposition and drying to obtain the CGP. (by machine translation)

Darwin's Warm Little Pond: A One-Pot Reaction for Prebiotic Phosphorylation and the Mobilization of Phosphate from Minerals in a Urea-Based Solvent

The poor reactivity of insoluble phosphates, such as apatite-group minerals, has been a long-appreciated obstacle for proposed models of prebiotic organophosphate formation. This obstacle presents a significant challenge to the nascent development of an RNA world and other models for the origins of life on Earth. Herein, we demonstrate that a scenario based on the formation of a urea/ammonium formate/water (UAFW) eutectic solution leads to an increase in phosphorylation when compared to urea alone for phosphate sources of varying solubility. In addition, under evaporative conditions and in the presence of MgSO4, the UAFW eutectic mobilizes the phosphate sequestered in water-insoluble hydroxyapatite, giving rise to a marked increase in phosphorylation. These results suggest that the prebiotic concentrations of urea in a geologically plausible evaporitic environment could solve the problem of organic phosphorylation on a prebiotic Earth.