1266101-38-5Relevant articles and documents
Boron/zinc exchange for the conjugate arylation of unsaturated Meldrum's acid derivatives
Jardim, Micaela,Baldassari, Lucas L.,Contreira, Maria Eduarda,Moro, Angélica V.,Lüdtke, Diogo S.
, (2020/01/31)
An approach for the conjugate arylation reaction of unsaturated Meldrum's acid derivatives is reported. The reaction takes place through a Boron-Zinc exchange reaction between arylboronic acids and diethylzinc and the subsequent transfer of thus generated reactive aryl groups to the β-position of the double bond of the Meldrum's derivatives. The compounds obtained are valuable synthetic intermediates and can give rise to bioactive molecules such as β,β-disubstituted carboxylic acids and amides.
Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers
Choi, Yeon-Hee,Baek, Du Jong,Seo, Seon Hee,Lee, Jae Kyun,Pae, Ae Nim,Cho, Yong Seo,Min, Sun-Joon
scheme or table, p. 215 - 219 (2011/02/26)
We have developed a facile synthesis of 3,3-diphenylpropanamides using Meldrum's acid derivatives as amide coupling components. The in vitro biological evaluation of the title compounds led to the identification of compound 1h, which has good inhibitory a
