1266343-30-9

Basic information

• Product Name: 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine
• Synonyms: 7-Bromo-6-chloro-9-methyl-7-deazapurine, 97%;7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-chloro-7-methyl-;JR-14014, 5-Bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, 95%
• CAS NO: 1266343-30-9
• Molecular Formula: C₇H₅BrClN₃
• Molecular Weight: 246.4917
• Product Categories: Aromatics;Bases & Related Reagents;Heterocycles;Intermediates;Nucleotides
• Mol File: 1266343-30-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 359.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.90±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.45±0.30(Predicted)
• CAS DataBase Reference: 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine(1266343-30-9)
• EPA Substance Registry System: 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine(1266343-30-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 1266343-30-9(Hazardous Substances Data)

Usage

Description

5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine is a light brown solid compound that serves as a key intermediate in the synthesis of indoline derivatives. It is characterized by its unique molecular structure, which includes a pyrrolo[2,3-d]pyrimidine core with a bromine atom at the 5th position, a chlorine atom at the 4th position, and a methyl group at the 7th position.

Uses

Used in Pharmaceutical Industry:
5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine is used as a key intermediate in the preparation of indoline derivatives, which are known as PERK inhibitors. These inhibitors play a crucial role in the development of therapeutic agents for various diseases, including neurodegenerative disorders and cancer. The compound's unique structure allows for the creation of potent and selective PERK inhibitors, which can modulate cellular signaling pathways and exhibit potential therapeutic effects.
Used in Chemical Research:
In addition to its pharmaceutical applications, 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine is also utilized in chemical research for the synthesis of various complex organic molecules. Its unique functional groups and structural features make it an attractive candidate for further exploration and modification, potentially leading to the discovery of new compounds with novel properties and applications.

Upstream product

• 7781-10-4 4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 1069473-61-5 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid 
• 1266343-32-1 7-methyl-4-(phenylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid 
• 1266343-34-3 N-(2-aminophenyl)-7-methyl-4-(phenylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide 
• 1266341-96-1 5-(1H-1,3-benzodiazol-2-yl)-7-methyl-N-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337530-96-7 7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337532-51-0 5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-51-7 5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1391053-27-2 1,1-dimethylethyl 5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indole-1-carboxylate 
• 1337531-26-6 5-{1-[(2-fluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-27-7 5-{1-[(3-fluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-86-8 5-{1-[(4-fluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-25-5 7-methyl-5-{1-[(2-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-29-9 7-methyl-5-{1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-39-1 5-{1-[(2-chlorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 

Relevant articles and documents

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

We have determined that a previously reported class of pyrrolo[2,3-d]pyrimidine-4-amines exhibit low binding to apical membrane antigen 1 (AMA1) and suffer from unattractive qualities, such as aggregation. We attempted to remove these traits by generating

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro- 1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumori-genesis and cancer cell survival stim

CHEMICAL COMPOUNDS

The invention is directed to substituted indoline derivatives. Specifically, the invention is directed to compounds according to Formula I wherein R1, R2 and R3 are defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response pathways, such as Alzheimer?s disease, stroke, Type 1 diabetes Parkinson disease, Huntington?s disease, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, atherosclerosis, and arrhythmias, and more specifically cancers of the breast, colon, pancreatic, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.