1337532-51-0

Basic information

• Product Name: 5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine
• Synonyms: 5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine;4-Amino-5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine;5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine;5-bromo-7-methylpyrrolo[2,3-d]pyrimidin-4-amine
• CAS NO: 1337532-51-0
• Molecular Formula: C₇H₇BrN₄
• Molecular Weight: 227.06128
• EINECS: 604-604-1
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates;Amines, Aromatics, Heterocycles, Intermediates
• Mol File: 1337532-51-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 196-198°C
• Boiling Point: 414.8±40.0 °C(Predicted)
• Appearance: /
• Density: 1.94±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Soluble in dichloromethane.
• PKA: 4.92±0.30(Predicted)
• CAS DataBase Reference: 5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine(1337532-51-0)
• EPA Substance Registry System: 5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine(1337532-51-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 1337532-51-0(Hazardous Substances Data)

Usage

Description

5-Bromo-7-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a chemical compound belonging to the class of indoline derivatives. It is characterized by its yellow-green solid appearance and is known for its potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
5-Bromo-7-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is used as a key intermediate compound in the synthesis of indoline derivatives. These derivatives are known as PERK inhibitors, which play a crucial role in the development of drugs targeting various diseases and conditions.
Used in Chemical Research:
In addition to its pharmaceutical applications, 5-Bromo-7-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is also utilized in chemical research for the development and study of new indoline-based compounds with potential applications in various industries.
Chemical Properties:
The compound is a yellow-green solid, which indicates its stability and potential for use in various chemical reactions and processes. Its unique chemical structure allows it to be a valuable building block in the synthesis of other compounds with specific properties and applications.

Upstream product

• 7781-10-4 4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 1266343-30-9 5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 
• 22276-99-9 4-amino-5-bromopyrrolo<2,3-d>pyrimidine 
• 74-88-4 methyl iodide 

Downstream Products

• 1337530-96-7 7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-51-7 5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-26-6 5-{1-[(2-fluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-27-7 5-{1-[(3-fluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-86-8 5-{1-[(4-fluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-25-5 7-methyl-5-{1-[(2-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-29-9 7-methyl-5-{1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-39-1 5-{1-[(2-chlorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-38-0 5-{1-[(3-chlorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-42-6 7-methyl-5-(1-{[3-(methyloxy)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-36-8 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone 
• 1337531-89-1 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone 
• 1337531-83-5 7-methyl-5-{1-[(2,3,5-trifluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1391053-27-2 1,1-dimethylethyl 5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indole-1-carboxylate 

Relevant articles and documents

PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS

Provided herein are compounds of formula (I), compositions, and methods useful for inhibiting PERK and for treating related conditions diseases, and disorders.

PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS TO TREAT VIRAL INFECTIONS

Provided herein are methods for treating a viral infection in a patient, comprising administering to said patient a therapeutically effective amount of a PERK inhibitor selected from a compound having the structure (I):

PHENYL-2-HYDROXY-ACETYLAMINO-2-METHYL-PHENYL COMPOUNDS

The present invention provides phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds, to pharmaceutical compositions comprising the compounds, to methods of using the compounds to treat physiological disorders such as cancer.