1267672-89-8

Basic information

• Product Name: (3-(4-tert-butylphenyl)isoxazol-5-yl)methanol
• Synonyms: (3-(4-tert-butylphenyl)isoxazol-5-yl)methanol
• CAS NO: 1267672-89-8
• Molecular Weight: 231.294
• Mol File: 1267672-89-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3-(4-tert-butylphenyl)isoxazol-5-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-(4-tert-butylphenyl)isoxazol-5-yl)methanol(1267672-89-8)
• EPA Substance Registry System: (3-(4-tert-butylphenyl)isoxazol-5-yl)methanol(1267672-89-8)

Safety Data

• Hazardous Substances Data: 1267672-89-8(Hazardous Substances Data)

Upstream product

• 939-97-9 4-tert-Butylbenzaldehyde 
• 107-19-7 propargyl alcohol 
• 180261-48-7 4-tert-butyl benzene carbaldehyde oxime 
• 61946-95-0 4-(tert-butyl)-N-hydroxybenzimidoyl chloride 

Relevant articles and documents

Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation

An efficient synthesis of bis(indolyl)methanes was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98 %). Solid support SiO2 was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring were synthesized via this method in excellent yields (> 94 %) using 3-substituted isoxazole-5-carbaldehydes and indole.

Efficient synthesis of bis-isoxazole ethers via 1,3-dipolar cycloaddition catalysed by Zn/Zn2+ and their antifungal activities

An efficient method was developed for synthesising isoxazoles. A series of novel bis-isoxazole ether compounds VI, VII and VIII were synthesised starting from different substituted aldehydes (I) via a 1,3-dispolar cycloaddition using Zn/Zn2+ as a catalyst; these were characterised by FT-IR, HRMS, 1H NMR and 13C NMR spectroscopy. In addition, the antimicrobial properties of the synthesised products were investigated. The synthesised compounds exhibited significant antifungal activities in comparison with the standard drugs, fluconazole and itraconazole. It was found that Candida albicans was sensitive to 2-substituted phenyl bis-isoxazole ethers bearing pyridyl.