1268830-30-3Relevant articles and documents
Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer
Wlodarczyk, Nicolas,Le Broc-Ryckewaert, Delphine,Gilleron, Pauline,Lemoine, Amélie,Farce, Amaury,Chavatte, Philippe,Dubois, Jo?lle,Pommery, Nicole,Hénichart, Jean-Pierre,Furman, Christophe,Millet, Régis
, p. 1178 - 1190 (2011/04/25)
A new class of potent farnesyltransferase inhibitors based on a 1,4-diazepane scaffold was synthesized with protein farnesyltransferase inhibition potencies in the low nanomolar range. The compounds block the growth on two hormone-resistant tumor prostati