89044-79-1

Basic information

• Product Name: 7-Phenyl-[1,4]diazepan-5-one
• Synonyms: 7-Phenyl-[1,4]diazepan-5-one;7-PhenylhoMopiperazin-5-one, 97%
• CAS NO: 89044-79-1
• Molecular Formula: C₁₁H₁₄N₂O
• Molecular Weight: 190
• Mol File: 89044-79-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 104-106℃
• Appearance: /
• Density: 1.075
• CAS DataBase Reference: 7-Phenyl-[1,4]diazepan-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Phenyl-[1,4]diazepan-5-one(89044-79-1)
• EPA Substance Registry System: 7-Phenyl-[1,4]diazepan-5-one(89044-79-1)

Safety Data

• Hazardous Substances Data: 89044-79-1(Hazardous Substances Data)

Usage

General Description

7-Phenyl-[1,4]diazepan-5-one, also known as felbamate, is a chemical compound that belongs to the class of anxiolytic drugs and anticonvulsants. It has been used in the treatment of epilepsy and partial seizures. The compound is believed to work by modulating the activity of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, which helps to reduce the occurrence of seizures. Felbamate has also been investigated for its potential as an anti-anxiety medication, as it appears to have calming effects on the central nervous system. However, the use of felbamate has been limited due to its association with serious side effects, including liver toxicity and aplastic anemia.

Upstream product

• 57552-95-1 7-phenyl-1,2,3,4-tetrahydro-1,4-diazepin-5-one 
• 89044-69-9 N-(2-bromoethyl)-4-phenylazetidin-2-one 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 100-42-5 styrene 
• 52341-70-5 N-chlorosulfonyl-4-phenylazetidin-2-one 

Downstream Products

• 28767-75-1 N¹-(2,4-dinitrophenyl)ethane-1,2-diamine 
• 220898-16-8 1-tert-butoxycarbonyl-7-phenyl-1,4-diazepan-5-one 
• 220898-23-7 1-tert-butoxycarbonyl-7-phenyl-1,4-diazepane 
• 1268830-15-4 4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane 
• 1268830-23-4 1-benzoyl-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-24-5 1-(2,4-dichlorobenzoyl)-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-25-6 1-(2-biphenoyl)-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-26-7 1-(1-naphthoyl)-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-27-8 1-cyclohexanoyl-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-28-9 1-(1-adamantanoyl)-4-tert-butoxycarbonyl-5-phenyl-1,4-diazepane 
• 1268830-29-0 1-benzoyl-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-30-3 1-(2,4-dichlorobenzoyl)-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-31-4 1-(2-biphenoyl)-5-phenyl-1,4-diazepane hydrochloride 
• 1268830-32-5 1-(1-naphthoyl)-5-phenyl-1,4-diazepane hydrochloride 

Relevant articles and documents

Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer

A new class of potent farnesyltransferase inhibitors based on a 1,4-diazepane scaffold was synthesized with protein farnesyltransferase inhibition potencies in the low nanomolar range. The compounds block the growth on two hormone-resistant tumor prostati

7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them

Neurokinin-antagonistic compounds corresponding to formula I: in which R1 is hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and R3 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R2 and R3 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring, R4 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and R5 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R4 and R5 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring, R6 is lower alkyl, halogen or trifluoromethyl, R7 is lower alkyl, halogen or trifluoromethyl, A is a -(CH2)n- group in which n represents an integer from 1 to 3, or an -NH-(CH2)m- group in which m represents an integer from 2 to 3, and B is an alkylene chain with 1 to 3 carbon atoms optionally substituted by lower alkyl, and physiologically acceptable salts thereof and processes for the preparation of these compounds.

ETUDE DE LA REACTIVE DE LA 7-PHENYL-1,4-DIAZEPINE-5-ONE

The reactivity of 7-phenyl-1,4-diazepin-5-one has been described.The new compounds obtained have been characterized by 1H NMR, IR, MS and microanalysis.