126991-60-4

Basic information

• Product Name: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)-
• Synonyms: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)-;4-(4-Chlorophenyl)cyclohex-3-ene-1-one Ethylene Ketal
• CAS NO: 126991-60-4
• Molecular Formula: C₁₄H₁₅ClO₂
• Molecular Weight: 250.72
• Product Categories: Aromatics;Heterocycles
• Mol File: 126991-60-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 364°C at 760 mmHg
• Flash Point: 141.7°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 3.63E-05mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)-(126991-60-4)
• EPA Substance Registry System: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)-(126991-60-4)

Safety Data

• Hazardous Substances Data: 126991-60-4(Hazardous Substances Data)

Usage

Description

1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)-, also known as 8-(4-chlorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene, is a pale yellow solid compound with the chemical formula C12H15ClO2. It is characterized by its unique spiro structure and the presence of a 4-chlorophenyl group. 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)is primarily used in organic synthesis due to its versatile chemical properties and potential applications in various industries.

Uses

Used in Organic Synthesis:
1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)is used as a key intermediate in organic synthesis for the production of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure and reactivity make it a valuable building block for the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)is used as a starting material or intermediate in the synthesis of various drug candidates. Its presence in the molecular structure can impart specific biological activities, such as anti-inflammatory, analgesic, or antipyretic properties, making it a promising candidate for the development of new medications.
Used in Agrochemical Industry:
1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)is also utilized in the agrochemical industry for the synthesis of pesticides, herbicides, and other crop protection agents. Its chemical properties can be tailored to target specific pests or weeds, providing an effective solution for agricultural challenges.
Used in Specialty Chemicals Industry:
In the specialty chemicals industry, 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-chlorophenyl)is employed in the development of high-performance materials, such as polymers, dyes, and coatings. Its unique structure and reactivity can be leveraged to create novel materials with improved properties, such as enhanced stability, durability, or specific functional groups.

InChI:InChI=1/C14H15ClO2/c15-13-3-1-11(2-4-13)12-5-7-14(8-6-12)16-9-10-17-14/h1-5H,6-10H2

Upstream product

• 126991-59-1 8-(4-chlorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 106-39-8 bromochlorobenzene 

Downstream Products

• 25253-51-4 4-(4-chlorophenyl)cyclohexanone monoehtylene ketal 
• 887578-35-0 1-amino-4-(4-chloro-phenyl)-cyclohexanecarboxylic acid 
• 868142-04-5 8-(4-chloro-phenyl)-1,3-diaza-spiro[4.5]decane-2,4-dione 
• 868142-29-4 8-(4-chloro-phenyl)-2,4-dioxo-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester 
• 14472-80-1 4-(4-chlorophenyl)cyclohexan-1-one 
• 1402080-52-7 5-(4-chlorophenyl)oxepan-2-one 
• 1203609-11-3 cis/trans-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1,4-dione 
• 1409956-73-5 trans-2-(4-(4-chlorophenyl)cyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1409956-79-1 cis-2-(4-(4-chlorophenyl)cyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1409956-84-8 cis/trans-2-bromo-2-(4-(4-chlorophenyl)cyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1409956-88-2 trans-2-bromo-2-(4-(4-chlorophenyl)cyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1409956-94-0 cis-2-bromo-2-(4-(4-chlorophenyl)cyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1409956-99-5 cis/trans-2-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1-ol 
• 1409957-04-5 trans-2-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1-ol 

Relevant articles and documents

The Silicon-Hydrogen Exchange Reaction: A Catalytic σ-Bond Metathesis Approach to the Enantioselective Synthesis of Enol Silanes

The use of chiral enol silanes in fundamental transformations such as Mukaiyama aldol, Michael, and Mannich reactions as well as Saegusa-Ito dehydrogenations has enabled the chemical synthesis of enantiopure natural products and valuable pharmaceuticals. However, accessing these intermediates in high enantiopurity has generally required the use of either stoichiometric chiral precursors or stoichiometric chiral reagents. We now describe a catalytic approach in which strongly acidic and confined imidodiphosphorimidates (IDPi) catalyze highly enantioselective interconversions of ketones and enol silanes. These "silicon-hydrogen exchange reactions"enable access to enantiopure enol silanes via tautomerizing σ-bond metatheses, either in a deprotosilylative desymmetrization of ketones with allyl silanes as the silicon source or in a protodesilylative kinetic resolution of racemic enol silanes with a carboxylic acid as the silyl acceptor.

Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method

Herein, we report the discovery of the first potent and selective inhibitor of TRPV6, a calcium channel overexpressed in breast and prostate cancer, and its use to test the effect of blocking TRPV6-mediated Ca2+-influx on cell growth. The inhib

Enantioselective baeyer-villiger oxidation: Desymmetrization of meso cyclic ketones and kinetic resolution of racemic 2-arylcyclohexanones

Catalytic enantioselective Baeyer-Villiger (BV) oxidations of racemic and meso cyclic ketones were achieved in the presence of chiral N,N'-dioxide-Sc III complex catalysts. The BV oxidations of prochiral cyclohexanones and cyclobutanones afforded series of optically active μ- and γ-lactones, respectively, in up to 99% yield and 95% ee. Meanwhile, the kinetic resolution of racemic 2-arylcyclohexanones was also realized via an abnormal BV oxidation. Enantioenriched 3-aryloxepan-2-ones, whose formation is counter to the migratory aptitude, were obtained preferentially. Both the lactones and the unreacted ketones were obtained with high ee values.