1409956-99-5

Basic information

• Product Name: cis/trans-2-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1-ol
• Synonyms: cis/trans-2-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1-ol
• CAS NO: 1409956-99-5
• Molecular Weight: 336.861
• Mol File: 1409956-99-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: cis/trans-2-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: cis/trans-2-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1-ol(1409956-99-5)
• EPA Substance Registry System: cis/trans-2-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1-ol(1409956-99-5)

Safety Data

• Hazardous Substances Data: 1409956-99-5(Hazardous Substances Data)

Upstream product

• 1409956-67-7 cis/trans-2-(4-(4-chlorophenyl)cyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1409956-62-2 2-(4-(4-chlorophenyl)cyclohex-1-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one 
• 25253-51-4 4-(4-chlorophenyl)cyclohexanone monoehtylene ketal 
• 126991-60-4 4-(4-chlorophenyl)cyclohex-3-enone monoehtylene ketal 
• 1409956-84-8 cis/trans-2-bromo-2-(4-(4-chlorophenyl)cyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 126991-59-1 8-(4-chlorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 106-39-8 bromochlorobenzene 
• 14472-80-1 4-(4-chlorophenyl)cyclohexan-1-one 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 1203609-11-3 cis/trans-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1,4-dione 
• 1409957-04-5 trans-2-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1-ol 
• 1409957-10-3 cis-2-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1-ol 
• 1409957-21-6 cis/trans-1a-(4-(4-chlorophenyl)cyclohexyl)naphtho[2,3-b]oxyrene-2,7(1aH,7aH)-dione 
• 1203609-10-2 cis-2-[4-(4-chlorophenyl)cyclohexyl]-1,4-naphthoquinone 
• 1409957-42-1 cis-1a-(4-(4-chlorophenyl)cyclohexyl)naphtho[2,3-b]oxirene-2,7(1aH,7aH)dione 

Relevant articles and documents

NOVEL METHOD FOR PREPARATION OF ATOVAQUONE

Provided is a process of preparation of 2-[trans,-4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy- 1,4-naphthoquinone, i.e. Atovaquone [I] which is cost effective, green, and eco-friendly process, without separation of any diastereomers or geometric isomers of intermediates obtained during the reactions. Also provided is separation of 'cis' and 'trans ' isomer of intermediates VI, VII and VIII through selective crystallization in an appropriate solvent. A method for converting 2-[cis,-4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone to 2-[trans-4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy-l,4-naphthoquinone in presence of Lewis/ Bronsted acid is also provided. A process for preparation of compound 2-(4-(4- chlorophenyl)- 1 -hydroxy cyclohexyl)-3,4-dihydronaphthalen- 1 (2H)-one [IV] comprising condensation of (1,2-dihydronaphthalen-4-yloxy)trimethylsilane [II] with 4-(4- chlorophenyl)cyclohexanone [III] in presence of Lewis acid in organic solvent. The invention also encompasses a highly efficient and atomeconomic process for synthesis of compound [III] i.e. 4-(4-chlorophenyl)cyclohexanone as well as a process for synthesis of 2-[cis-4-(4'- chlorophenyl)cyclohexyl]-3-hydroxy-l,4-naphthoquinone. Further provided is a process for isomerization of cis- Atovaquone i.e. 2-[cis-4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy-l,4- naphthoquinone to tnms-Atovaquone i.e. 2-[trans-4-(4'-chlorophenyl)cyclohexyl]-3- hydroxy- 1,4-naphthoquinone in presence of Lewis acid.