127118-87-0

Basic information

• Product Name: Formamide, N-[2-(4-chlorophenyl)-2-oxoethyl]-N-formyl-
• CAS NO: 127118-87-0
• Molecular Formula: C10H8ClNO3
• Molecular Weight: 225.631
• Mol File: 127118-87-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Formamide, N-[2-(4-chlorophenyl)-2-oxoethyl]-N-formyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-[2-(4-chlorophenyl)-2-oxoethyl]-N-formyl-(127118-87-0)
• EPA Substance Registry System: Formamide, N-[2-(4-chlorophenyl)-2-oxoethyl]-N-formyl-(127118-87-0)

Safety Data

• Hazardous Substances Data: 127118-87-0(Hazardous Substances Data)

Upstream product

• 18197-26-7 sodium diformamide 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 3755-85-9 4-Chlor-ω-formylamino-acetophenon 
• 5467-71-0 4-chlorophenacylamine hydrochloride 
• 41870-82-0 2-amino-1-(4-chlorophenyl)ethanol 

Relevant articles and documents

A CONVENIENT PREPARATION OF AMINOMETHYL ARYL KETONES AND THEIR DERIVATIVES

A convenient preparation of N-phenacyl diformamides, N-phenacyl formamides and aminomethyl aryl ketone hydrochlorides from aryl bromomethyl ketones and sodium diformylamide was described.

Facile generation of a library of 5-aryl-2-arylsulfonyl-1,3-thiazoles

Treatment of N,N-diformylaminomethyl aryl ketones with phosphorus pentasulfide/triethylamine in chloroform gives 5-arylthiazoles directly in good yield. The 5-aryl-1,3-thiazole core has been successfully functionalised at the 2-position to yield, over two

A Convenient Synthesis of Aminomethyl Ketones (α-Amino Ketones)

Several N,N-diformylaminomethyl ketones 3 were prepared by treating the respective bromomethylketone 1 with sodium diformylamide in acetonitrile at room temperature.This reaction produced from N-formylaminomethyl ketones 4 when ethanol was used as the solvent.One of the formyl groups of N,N-difomylaminomethyl ketones was selectively removed by using a catalytic amount of sodium or potassium hydroxide in alcohol to the corresponding N-formylaminomethyl ketones 4.The formyl groups of both N,N-diformyl- and N-formylaminomethyl ketones could be easily removed by either5percent hydrochloric acid in ethanol or 6N hydrochloric acid to give the corresponding aminomethyl ketone hydrochlorides 5.These reactions are general and give high yield of the products.