127333-83-9Relevant articles and documents
Preparation of eight-membered cyclic ethers by Lewis acid promoted acetal-alkene cyclizations
Blumenkopf, Todd A.,Bratz, Matthias,Casta?eda, Armando,Look, Gary C.,Overman, Larry E.,Rodriguez, Domingo,Thompson, Andrew S.
, p. 4386 - 4399 (1990)
The Lewis acid promoted cyclization of 20 5-alkenyl acetals is reported. Oxocenes with Δ4 unsaturation (3,6,7,8-tetrahydro-2H-oxocins) can be accessed in this convenient fashion with moderate to excellent efficiency and with perfect regiochemic