127351-04-6Relevant articles and documents
Synthesis, anticancer activity and docking of some substituted benzothiazoles as tyrosine kinase inhibitors
Bhuva, Hemal A.,Kini, Suvarna G.
experimental part, p. 32 - 37 (2011/10/09)
Protein tyrosine kinases occupy a central position in the control of cellular proliferation and its inactivation might lead to the discovery of a new generation anticancer compounds. Substituted benzothiazoles have been found to mimic the ATP-competitive
ANTIMYCOBACTERIAL THIOBENZANILIDES
Waisser, Karel,Houngbedji, Nestor,Machacek, Milos,Sekera, Miroslav,Urban, Josef,Odlerova, Zelmira
, p. 307 - 316 (2007/10/02)
A group of 30 thiobenzanilides active against Mycobacterium kansasii have been synthesized and their 1H NMR and UV spectra and RM values (TLC on silica gel impregnated with methylsilicone oil) have been measured.From the correlation between the chemical shifts of the thioamide proton in the 1H NMR spectra and the Hammett constants it can be concluded that the substituents in both aromatic rings uniformly affect the electron density of the thioamide group.The antimycobacterial activity is probably connected with local molecular parameters and can be considered to be approximately additive with respect to both parts of the molecule.