127500-37-2

Basic information

• Product Name: 2-chloro-2-fluoro-N-(2-phenylethyl)acetamide
• Synonyms: 2-chloro-2-fluoro-N-(2-phenylethyl)acetamide
• CAS NO: 127500-37-2
• Molecular Weight: 215.655
• Mol File: 127500-37-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-2-fluoro-N-(2-phenylethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-2-fluoro-N-(2-phenylethyl)acetamide(127500-37-2)
• EPA Substance Registry System: 2-chloro-2-fluoro-N-(2-phenylethyl)acetamide(127500-37-2)

Safety Data

• Hazardous Substances Data: 127500-37-2(Hazardous Substances Data)

Upstream product

• 401-56-9 ethyl chlorofluoroacetate 
• 64-04-0 phenethylamine 

Downstream Products

• 958643-14-6 2-chloro-2-fluoro-N-(2-phenylethyl)ethanamine 

Relevant articles and documents

Synthesis and reactivity of 1-substituted 2-fluoro- and 2,2-difluoroaziridines

(Chemical Equation Presented) A straightforward synthesis toward 2-fluorinated aziridines was developed via ring closure of β-fluorinated β-chloroamines, which were obtained via reduction of the corresponding α-fluorinated amides by borane. When 1-benzyl-2-fluoroaziridine was treated with methanol, reaction occurred at the 2-position, giving rise to N-benzyl-2,2-dimethoxyethylamine, while in the case of 1-benzyl-2,2- difluoroaziridine the 3-position was attacked, giving rise to N-benzyl-2-methoxyacetamide. These reactions point to the divergent reactive behavior of monofluoro- and difluoroaziridines.