401-56-9

Basic information

• Product Name: ETHYL CHLOROFLUOROACETATE
• Synonyms: chlorofluoro-aceticaciethylester;ETHYL CHLOROFLUOROACETATE;CHLOROFLUOROACETIC ACID ETHYL ESTER;Ethylchlorofluoroacetate,98%;Ethyl chlorofluoroacetate 97%;Ethylchlorofluoroacetate97%;2-Chloro-2-fluoroacetic acid ethyl ester;Fluorochloroacetic acid ethyl ester
• CAS NO: 401-56-9
• Molecular Formula: C₄H₆ClFO₂
• Molecular Weight: 140.54
• EINECS: 206-930-5
• Product Categories: Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;C2 to C5;Carbonyl Compounds;Esters;Alkyl Fluorinated Building Blocks;Building Blocks;C2 to C5
• Mol File: 401-56-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 133 °C(lit.)
• Flash Point: 125 °F
• Appearance: clear colorless liquid
• Density: 1.212 g/mL at 25 °C(lit.)
• Vapor Pressure: 10.4mmHg at 25°C
• Refractive Index: n20/D 1.396(lit.)
• BRN: 1748679
• CAS DataBase Reference: ETHYL CHLOROFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL CHLOROFLUOROACETATE(401-56-9)
• EPA Substance Registry System: ETHYL CHLOROFLUOROACETATE(401-56-9)

Safety Data

• Hazard Codes: C,F,Xi
• Statements: 10-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2920 8/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 401-56-9(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

Ethyl chlorofluoroacetate may be used in the synthesis of:chlorofluoroacetamideethyl α-fluoro silyl enol etherchlorofluoroacetyl chloride

InChI:InChI=1/C4H6ClFO2/c1-2-8-4(7)3(5)6/h3H,2H2,1H3/t3-/m0/s1

Upstream product

• 310-71-4 ethoxyflurane 
• 459-72-3 ethyl 2-fluoroacetate 
• 562-85-6 chloro-fluoro-orthoacetic acid triethyl ester 
• 623-73-4 diazoacetic acid ethyl ester 
• 64-17-5 ethanol 
• 359-34-2 chlorofluoroacetyl fluoride 
• 359-32-0 chlorofluoroacetyl chloride 

Downstream Products

• 730-71-2 2-chloro-1,1-bis-(4-chloro-phenyl)-2-fluoro-ethanol 
• 401-58-1 ethyl 2-fluoro-2-iodoacetate 
• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 129600-91-5 ethyl 2-(p-chlorophenylthio)-2-fluoroacetate 
• 39547-75-6 [4-(Ethoxycarbonyl-fluoro-methanesulfonyl)-benzenesulfonyl]-fluoro-acetic acid ethyl ester 
• 20808-13-3 ethyl 2-fluoro-2-(phenylsulfonyl)acetate 
• 39547-73-4 (4-Chloro-benzenesulfonyl)-fluoro-acetic acid ethyl ester 
• 39547-74-5 Fluoro-(4-nitro-benzenesulfonyl)-acetic acid ethyl ester 
• 216776-67-9 (5-Cyano-6-methyl-2-phenyl-pyrimidin-4-ylsulfanyl)-fluoro-acetic acid ethyl ester 
• 106372-59-2 ethyl 2-fluoro-2-(phenylsulfanyl)acetate 
• 142753-36-4 α-fluoro-α-(phenylselanyl)acetic acid ethyl ester 
• 925693-54-5 2-chloro-2-fluoro-1-(4-methoxyphenyl) ethanone 
• 127500-37-2 2-chloro-2-fluoro-N-(2-phenylethyl)acetamide 
• 216578-83-5 (RS)-N-benzyl-2-chloro-2-fluoroethanamide 

Relevant articles and documents

Synthesis, Structure, High-Resolution Spectroscopy, and Laser Chemistry of Fluorooxirane and 2,2-[2H2]-Fluorooxirane

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REACTION OF ALKYL 2-CHLORO-1,1,2-TRIFLUOROETHYL ETHERS WITH LEWIS ACIDS

Ethyl 2-chloro-1,1,2-trifluoroethyl ether heated with boron trifluoride etherate gave ethyl fluoride and chlorofluoroacetyl fluoride.When heated with aluminium chloride, it afforded a mixture of ethyl fluoride, ethyl chloride, chlorofluoroacetyl fluoride, and chlorofluoroacetyl chloride.Treatment of the acyl halides with ethanol yielded ethyl chlorofluoroacetate.Butyl and octyl 2-chloro-1,1,2-trifluoroethyl ethers gave directly butyl and octyl chlorofluoroacetates, respectively, under similar conditions.