216776-67-9

Basic information

• Product Name: (5-Cyano-6-methyl-2-phenyl-pyrimidin-4-ylsulfanyl)-fluoro-acetic acid ethyl ester
• Synonyms: (5-Cyano-6-methyl-2-phenyl-pyrimidin-4-ylsulfanyl)-fluoro-acetic acid ethyl ester
• CAS NO: 216776-67-9
• Molecular Weight: 331.37
• Mol File: 216776-67-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5-Cyano-6-methyl-2-phenyl-pyrimidin-4-ylsulfanyl)-fluoro-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (5-Cyano-6-methyl-2-phenyl-pyrimidin-4-ylsulfanyl)-fluoro-acetic acid ethyl ester(216776-67-9)
• EPA Substance Registry System: (5-Cyano-6-methyl-2-phenyl-pyrimidin-4-ylsulfanyl)-fluoro-acetic acid ethyl ester(216776-67-9)

Safety Data

• Hazardous Substances Data: 216776-67-9(Hazardous Substances Data)

Upstream product

• 401-56-9 ethyl chlorofluoroacetate 
• 2228-12-8 6-methyl-4-phenyl-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile 

Downstream Products

• 216777-55-8 5-amino-6-benzoyl-4-methyl-2-phenylthieno[2,3-d]pyrimidine 
• 115073-27-3 6-acetyl-5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine 
• 153776-13-7 5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidin-6-carboxamide 
• 154366-93-5 5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine-6-carbonitrile 
• 216776-76-0 6-Fluoro-4-methyl-2-phenyl-thieno[2,3-d]pyrimidin-5-ylamine 

Relevant articles and documents

An easy direct conversion of pyridine- and pyrimidine-thiones into multi-fused heterocyclic compounds

The reaction of azine-thiones with ethyl chlorofluoroacetate afforded 2- fluorothienoazines. The latter underwent self-condensation and gave multi- fused heterocyclic compounds. A wide range of unique heterocycles could be obtained on treatment of 2-fluorothienoazines with nitrogen nucleophilic reagents. The reactivity of the pyrimidine-thiones towards a variety of electrophilic reagents was studied. Chemical and spectroscopic evidence of the newly synthesized compounds are described.