127636-31-1

Basic information

• Product Name: 1,3-Propanedione, 1-(4-chlorophenyl)-3-(4-methylphenyl)-
• CAS NO: 127636-31-1
• Molecular Formula: C16H13ClO2
• Molecular Weight: 272.731
• Mol File: 127636-31-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,3-Propanedione, 1-(4-chlorophenyl)-3-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanedione, 1-(4-chlorophenyl)-3-(4-methylphenyl)-(127636-31-1)
• EPA Substance Registry System: 1,3-Propanedione, 1-(4-chlorophenyl)-3-(4-methylphenyl)-(127636-31-1)

Safety Data

• Hazardous Substances Data: 127636-31-1(Hazardous Substances Data)

Upstream product

• 1126-46-1 Methyl 4-chlorobenzoate 
• 122-00-9 para-methylacetophenone 
• 101272-32-6 2,3-dibromo-1-(4-chloro-phenyl)-3-p-tolyl-propan-1-one 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 1384511-99-2 C₁₆H₁₂BClF₂O₂ 
• 86508-29-4 1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione 
• 131138-54-0 3-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazole 
• 193486-30-5 1-(4-chlorophenyl)-2,2-dimethyl-3-(4-methylphenyl)-propane-1,3-dione 

Relevant articles and documents

A metal-free strategy for the cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol

Here, we report a metal-free approach for the construction of methylene-bridged bis-1,3-dicarbonyl compounds via cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol. In addition, we have extended this methodology to synthesize tetra-substituted pyridine derivatives using 1,3-dicarbonyl, 2-methoxyethanol and NH4OAc in one step. The key advantages include accepting a wide range of substrates, utilizing O2 as the sole oxidant, and synthesizing biologically active compounds such as 1,4-dihydropyridine and pyrazole. This journal is

Preparation and spectroscopic properties of some new diaroylmethanatoboron difluoride derivatives

Five diaroylmethanatoboron difluoride derivatives were prepared from aryl methyl ketones via Claisen condensation with aromatic esters and followed by complexation with boron trifluoride etherate. Their structures and spectroscopic properties were studied

Imidazo[2,1-b]thiazole derivatives XII. Synthesis and immunoactivity in vitro on human T lymphocyte of several 3-aroylmethyl and 2-aroyl-3-methyl(aryl)-5,6-dihydroimidazo[2,1-b]thiazoles

To estimate the influence of aryl group position on the immunostimulant properties of imidazo[2,1-b]thiazole derivatives, several compounds were obtained and tested, versus tetramisole hydrochloride, on the mobilisation of CD2 receptor by human T lymphocyte. The synthesis use the action of monobrominated β-diketones on the 2-mercaptoimidazoline. So, 1-aryl-4-bromobutane-1,3-diones lead to 3-aroylmethyl-5,6-dihydroimidazo[2,1-b]thiazoles 4. Same, 1-aryl-2-bromobutane-1,3-diones and 1,3-diaryl-2-bromopentane-1,3-diones give respectively 3-aroyl-2-methyl-5,6-dihydroimidazo[2,1-b]thiazoles 5 and 3-aroyl-2-aryl-5,6-dihydroimidazo[2,1-b]thiazoles 6. Better yields are obtained when the reaction presents two steps. The first one, realized in acetone at room temperature, leads to an intermediate S-substituted 4,5-dihydroimidazole which, in second step, is cyclized in imidazo[2,1-b]thiazole compound via an unisolated carbinolamine. This one explains the univocal formation of 5 derivatives and the feasible blending in case of 6. The immunoactivity of several imidazothiazoles 4, 5 and 6 is lower that them of 6-aryl substituted compounds and particularly that the levamisole which is the reference product in this series.