86508-29-4

Basic information

• Product Name: 1-(4-CHLOROPHENYL)-2-(4-METHYLPHENYL)ETHANE-1,2-DIONE
• Synonyms: 1-(4-CHLOROPHENYL)-2-(4-METHYLPHENYL)ETHANE-1,2-DIONE;1-(4-CHLOROPHENYL)-2-(4-METHYLPHENYL)ETHAN-1,2-DIONE
• CAS NO: 86508-29-4
• Molecular Formula: C₁₅H₁₁ClO₂
• Molecular Weight: 258.7
• Mol File: 86508-29-4.mol
• Article Data: 18

Chemical Properties

• Melting Point: 108℃
• Boiling Point: 413.2°C at 760 mmHg
• Flash Point: 174.5°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 4.9E-07mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)-2-(4-METHYLPHENYL)ETHANE-1,2-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)-2-(4-METHYLPHENYL)ETHANE-1,2-DIONE(86508-29-4)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)-2-(4-METHYLPHENYL)ETHANE-1,2-DIONE(86508-29-4)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 86508-29-4(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione, also known as chlorthalidone, is a chemical compound that belongs to the class of thiazide diuretics. It is used in the treatment of high blood pressure and edema (fluid retention) caused by various medical conditions such as heart failure, liver cirrhosis, and kidney disorders. Chlorthalidone works by increasing the excretion of water and sodium from the body, thus reducing the volume of blood and lowering blood pressure. It is usually taken orally in the form of a tablet and is often prescribed as a single therapy or in combination with other medications for better control of blood pressure. As with any medication, chlorthalidone may cause certain side effects, including dizziness, weakness, and dehydration, and should be used under the supervision of a healthcare professional.

InChI:InChI=1/C15H11ClO2/c1-10-2-4-11(5-3-10)14(17)15(18)12-6-8-13(16)9-7-12/h2-9H,1H3

Upstream product

• 86508-32-9 <(4-Chlorphenyl)(4-methylbenzoyloxy)methyl>triphenylphosphonium-chlorid 
• 62006-19-3 2-(4-Chlorophenyl)-1-(4-methylphenyl)ethan-1-one 
• 1878-66-6 4-chlorophenylacetic Acid 
• 25026-34-0 4-chlorophenacetyl chloride 
• 874-60-2 4-methyl-benzoyl chloride 
• 99-91-2 para-chloroacetophenone 
• 108-88-3 toluene 
• 3041-83-6 (E)-4-chloro-4'-methylstilbene 
• 13565-39-4 3-(4-chlorophenyl)-1-p-tolylprop-2-en-1-one 
• 106-47-8 4-chloro-aniline 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 122-01-0 4-chloro-benzoyl chloride 
• 127636-31-1 1-(4-methylphenyl)-3-(4-chlorophenyl)propane-1,3-dione 

Downstream Products

• 811441-80-2 5-(4-chlorophenyl)-6-(4-methylphenyl)pyrazine-2,3-dicarbonitrile 
• 1207377-64-7 C₁₆H₁₃ClN₂O₂ 
• 1207377-58-9 C₁₇H₁₅ClN₄O₂ 

Relevant articles and documents

Visible-Light-Induced Photocatalytic Oxidative Decarboxylation of Cinnamic Acids to 1,2-Diketones

A concerted metallophotoredox catalysis has been realized for the efficient decarboxylative functionalization of α,β-unsaturated carboxylic acids with aryl iodides in the presence of perylene bisimide dye to afford 1,2-diketones.

Synthesis of 1,2-diketones by mercury-catalyzed alkyne oxidation

The first mercury-catalyzed synthesis of 1,2-diketones by alkyne oxidation has been developed. This inexpensive method extends the potential of mercury catalysis and allows the rapid construction of various 1,2-diketones and α-carbonyl amides in good yields with high functional group tolerance.

Palladium-Catalyzed Oxidative C≡C Triple Bond Cleavage of 2-Alkynyl Carbonyl Compounds Toward 1,2-Dicarbonyl Compounds?

A new, general palladium-catalyzed oxidative strategy for the cleavage of the C≡C triple bond is presented. By employing PdCl2, CuBr2, TEMPO and air as the catalytic system and H2O as the carbonyl oxygen atom source, a wide range of 2-alkynyl carbonyl compounds, including 1,3-disubstituted prop-2-yn-1-ones, propiolamides and propiolates, lost an alkynyl carbon to access various 1,2-dicarbonyl compounds, e.g., 1,2-diones, 2-keto amides and 2-keto esters, through Wacker oxidation, intramolecular cyclization and C—C bond cleavage cascades.