62006-19-3

Basic information

• Product Name: 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone
• Synonyms: 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone;2-(4-Chlorophenyl)-4'-methylacetophenone;2-(4-chlorophenyl)-1-(4-methylphenyl)ethanone
• CAS NO: 62006-19-3
• Molecular Formula: C₁₅H₁₃ClO
• Molecular Weight: 244.71612
• Mol File: 62006-19-3.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone(62006-19-3)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone(62006-19-3)

Safety Data

• Hazardous Substances Data: 62006-19-3(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)-1-(p-tolyl)ethanone, also known as 4'-Chloroacetophenone, is a chemical compound with the molecular formula C14H11ClO. It is a substituted acetophenone, which is a type of organic compound widely used in the production of pharmaceuticals, fragrances, and other fine chemicals. This specific compound is widely used as an intermediate in the synthesis of various pharmaceuticals, especially those with analgesic or anti-inflammatory properties. It is also used in the production of perfumes and flavoring agents. Due to its chemical structure, it is considered to be a potentially harmful and irritating substance, and proper safety precautions should be followed when handling it.

Upstream product

• 108-88-3 toluene 
• 25026-34-0 4-chlorophenacetyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 104-85-8 para-methylbenzonitrile 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 1878-66-6 4-chlorophenylacetic Acid 
• 7179-73-9 2-(4-chlorophenyl)-1-(p-tolyl)ethanol 
• 5142-75-6 tri(p-tolyl)bismuth 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 140-53-4 p-chlorobenzyl cyanide 
• 26037-50-3 tri(4-chloro)benzyl aluminium 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 77989-07-2 3-p-chlorophenyl-4-p-tolyl-1,2,5-thiadiazole 
• 86508-29-4 1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione 
• 1041810-86-9 (Z)-3-chloro-2-(4-chlorophenyl)-3-(p-tolyl)propenal 
• 1221155-43-6 3-(azepan-1-yl)-2-(4-chlorophenyl)-1-(4-methylphenyl)propan-1-one 
• 1416727-81-5 N-(2-(4-chlorophenyl)-1-p-tolylethyl)-4-methoxyaniline 
• 1416728-01-2 N-(2-(4-chlorophenyl)-1-p-tolylethylidene)-4-methoxyaniline 
• 343596-22-5 2-bromo-2-(4-chlorophenyl)-1-(4-methylphenyl)ethanone 

Relevant articles and documents

An Oxidant- And Catalyst-Free Synthesis of Dibenzo[ a, c ]carbazoles via UV Light Irradiation of 2,3-Diphenyl-1 H -indoles

An efficient methodology for the synthesis of dibenzo[a,c]- carbazoles via annulation of 2,3-diphenyl-1H-indoles in EtOH under UV light irradiation (λO = 365 nm) along with hydrogen evolution is described. This method exhibits the advantages of mild reaction conditions, no requirement of any oxidants and catalysts, and release of hydrogen as the only byproduct. Notably, the mechanism investigation confirms that the trans-4b,8a-dihydro-9H-dibenzo[a,c]carbazole intermediate could convert into cis-4b,8a-dihydro-9H-dibenzo[a,c]carbazole, which relies on the nitrogen atom of the indole ring. This is followed by intramolecular dehydrogenation which yields the dibenzo[a,c]carbazoles. 2021. Thieme. All rights reserved.

Design and synthesis of 4,5-diaryl/heteroarylthiophene-2-carboxylic acid derivatives and evaluation of their biological activities

Synthesis, characterization and biological activity of novel 4,5-diaryl/heteroaryl thiophene-2-carboxylic acid derivatives are described. Aryl/heteroaryl esters were converted to substituted thiophene esters via a Vilsmeier-Haack reaction, which were then hydrolyzed to 4,5-diaryl/heteroaryl thiophene-2-carboxylic acid derivatives 8a-h. All products were characterized by 1H NMR, 13C NMR, IR and MS. Antibacterial activity of the synthesized compounds against two Gram-positive and two Gram-negative bacteria, as well as their anticancer activity against PC-3 cell line (human prostate cancer cell lines) were evaluated.

Tandem nucleophilic addition-Oppenauer oxidation of aromatic aldehydes to aryl ketones with triorganoaluminium reagents

In the presence of pinacolone, the in situ prepared triorganoaluminium reagents reacted with aromatic aldehydes to give ketones in moderate to high yield. We propose that the products are formed via a tandem organoaluminium reagents addition-Oppenauer oxidation sequence. The Royal Society of Chemistry 2013.