13565-39-4

Basic information

• Product Name: 2-Propen-1-one, 3-(4-chlorophenyl)-1-(4-methylphenyl)-, (2E)-
• CAS NO: 13565-39-4
• Molecular Formula: C16H13ClO
• Molecular Weight: 256.732
• Mol File: 13565-39-4.mol
• Article Data: 76

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(4-chlorophenyl)-1-(4-methylphenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(4-chlorophenyl)-1-(4-methylphenyl)-, (2E)-(13565-39-4)
• EPA Substance Registry System: 2-Propen-1-one, 3-(4-chlorophenyl)-1-(4-methylphenyl)-, (2E)-(13565-39-4)

Safety Data

• Hazardous Substances Data: 13565-39-4(Hazardous Substances Data)

Upstream product

• 32045-77-5 2,3-Dibromo-3-(4-chloro-phenyl)-1-p-tolyl-propan-1-one 
• 104-88-1 4-chlorobenzaldehyde 
• 619-41-0 4-(bromoacetyl)toluene 
• 122-00-9 para-methylacetophenone 
• 873-76-7 para-Chlorobenzyl alcohol 
• 315180-21-3 3-(4-chlorophenyl)-1-(4-methylphenyl)-1-propanone 
• 1073-67-2 4-vinylbenzyl chloride 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 1615-02-7 p-chlorocinnamic acid 
• 766-97-2 4-n-methylphenylacetylene 
• 104-87-0 4-methyl-benzaldehyde 
• 154230-29-2 (E)-4-chlorostyrylboronic acid 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 

Downstream Products

• 367935-01-1 2-[1-(4-Chloro-phenyl)-3-oxo-3-p-tolyl-propyl]-malonic acid diethyl ester 
• 32045-77-5 2,3-Dibromo-3-(4-chloro-phenyl)-1-p-tolyl-propan-1-one 
• 1251959-45-1 3-chloro-3-(4-chlorophenyl)-1-p-tolylpropan-1-one 
• 1210051-86-7 3-(4-chlorophenyl)-1-(4-methylphenyl)-3-phenylsulphanylpropan-1-one 
• 62953-34-8 4-(4-chloro-phenyl)-2-phenanthren-3-yl-6-p-tolyl-pyridine 
• 315180-21-3 3-(4-chlorophenyl)-1-(4-methylphenyl)-1-propanone 
• 13565-39-4 3-(4-chlorophenyl)-1-p-tolylprop-2-en-1-one 
• 1147357-09-2 C₁₆H₁₅Cl 
• 1175523-06-4 C₁₆H₁₅Cl 
• 19672-63-0 1-(4-chlorophenyl)-3-(4-methylphenyl)prop-2-en-1-one 
• 1427302-38-2 1-(5-(4-chlorophenyl)-2-methyl-4-(4-methylbenzoyl)-1H-pyrrol-3-yl)-2,2,2-trifluoroethanone 
• 1427302-16-6 1-(5-(4-chlorophenyl)-2-methyl-4-(4-methylbenzoyl)-1H-pyrrol-3-yl)ethanone 

Relevant articles and documents

Potassium Natural Asphalt Sulfonate (K-NAS): Synthesis and characterization as a new recyclable solid basic nanocatalyst and its application in the formation of carbon–carbon bonds

In this research, we synthesized and characterized a new heterogeneous basic nanocatalyst and its catalytic application was studied in the Claisen-Schmidt and Knoevenagel condensations. In order to prepare this nanocatalyst, first, the Iranian natural asphalt was sulfonated with the concentrated sulfuric acid and then, converted to the potassium natural asphalt sulfonate (K-NAS). In order to characterization of the nanocatalyst, used of FT-IR spectroscopy, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), inductively coupled plasma (ICP) and thermogravimetric analysis (TGA) techniques. This new basic heterogeneous nanocatalyst have advantages such as being eco-friendly, huge specific surface area, high reactivity and recyclability.

Palladium-catalyzed direct cross-coupling of potassium styryltrifluoroborates and benzoyl chlorides - A one step method for chalcone synthesis

A direct cross-coupling reaction of benzoyl chlorides and potassium styryltrifluoroborates to the corresponding α,β-unsaturated aromatic ketones in the presence of PdCl2(dtbpf) catalyst under microwave heating is developed.

Novel potent and selective DPP-4 inhibitors: Design, synthesis and molecular docking study of dihydropyrimidine phthalimide hybrids

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as antihyperglycemic agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in combination with other antidiabetic drugs. Methods: A novel series of dihydropyrimidine phthalimide hybrids was synthesized and evaluated for their in vitro and in vivo DPP-4 inhibition activity and selectivity using alogliptin as reference. Oral glucose tolerance test was assessed in type 2 diabetic rats after chronic treatment with the synthesized hybrids ± metformin. Cytotoxicity and antioxidant assays were performed. Additionally, molecular docking study with DPP-4 and structure activity relationship of the novel hybrids were also studied. Results: Among the synthesized hybrids, 10g, 10i, 10e, 10d and 10b had stronger in vitro DPP-4 inhibitory activity than alogliptin. Moreover, an in vivo DPP-4 inhibition assay revealed that 10g and 10i have the strongest and the most extended blood DPP-4 inhibitory activity compared to alogliptin. In type 2 diabetic rats, hybrids 10g, 10i and 10e exhibited better glycemic control than alogliptin, an effect that further supported by metformin combination. Finally, 10j, 10e, 10h and 10d had the highest radical scavenging activity in DPPH assay. Conclusions: Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.

Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst

Phthalhydrazide immobilized on TiO2-coated nano Fe3O4 (Fe3O4-P) was synthesized and characterized by FT-IR, XRD, SEM, EDS and VSM analysis. The resulting magnetic nanocatalyst was used as a catalyst for the synthesis of chalcone derivatives which affords the desired products in good to excellent yields. This catalyst can be isolated readily after completion of the reaction by an external magnetite field and reused several times without significant loss of activity.