12771-68-5 Usage
Description
Ancymidol, also known as α-cyclopropyl-α-(4-methoxyphenyl)-5-pyrimidinemethanol (EL-531), is a synthetic pyrimidine analogue and a plant growth retardant. It is a white to buff-colored crystalline or granular solid with a slightly aromatic odor. Ancymidol functions as a weak fungitoxic by inhibiting gibberellin biosynthesis, which leads to reduced plant growth, internode elongation, and more compact plants.
Uses
Used in Plant Growth Regulation:
Ancymidol is used as a plant growth regulator for promoting more compact and uniform growth in a wide variety of container-grown bedding and foliage plants. This application helps in the commercial production of plants such as chrysanthemums, Easter lilies, and poinsettias.
Used in Cytochrome P450 Inhibition Studies:
Ancymidol has been utilized as a cytochrome P450 inhibitor to study its effects on Cyanidioschyzon merolae strain, providing valuable insights into the role of this enzyme in various biological processes.
Used in Pharmaceutical Applications:
Although not explicitly mentioned in the provided materials, Ancymidol's ability to inhibit specific enzymes could potentially make it a candidate for pharmaceutical applications, particularly in the development of drugs targeting enzyme-related diseases or conditions.
Biochem/physiol Actions
Ancymidol is a pyrimidine-class plant cell endocrine disruptor plant growth regulator that interferes with gibberellin and cellulose biosynthesis.
Potential Exposure
Ancymidol is a plant growth regulator
registered for treating container-grown herbaceous plants,
ornamental woody shrubs, and bedding plants grown in
greenhouses and other plant bedding areas for primarily
commercial production. Growth regulator used on plants
such as chrysanthemums, certain lilies, and poinsettias
effects produced by ancymidol are the result of inhibition
of gibberellin biosynthesis. It produces a more compact
growth form by suppressing elongation.
Incompatibilities
Dust may form explosive mixture with
air. Ancymidol may react vigorously with oxidizing agents.
Mixtures with concentrated hydrogen peroxide or strong
mineral acids (e.g., nitric, sulfuric, perchloric) may cause
explosions. Mixtures with hypochlorous acid, lead perchlorate,
chlorine, bleaches, including sodium hypochlorite;
mixed water/carbon tetrachloride solution; trichloroisocyanuric
acid form methyl hypochlorite, which can be explosive,
especially when exposed to sunlight or heat. May
react with metallic aluminum at high temperature. Flow or
agitation of substance may generate electrostatic charges
due to low conductivity; ground all equipment containing
this material. May attacks some plastics, rubber, and
coatings.
Waste Disposal
Dispose of contents and container
to an approved waste disposal plant. All federal, state,
and local environmental regulations must be observed.
References
Check Digit Verification of cas no
The CAS Registry Mumber 12771-68-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,7,7 and 1 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 12771-68:
(7*1)+(6*2)+(5*7)+(4*7)+(3*1)+(2*6)+(1*8)=105
105 % 10 = 5
So 12771-68-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H16N2O2/c1-19-14-6-4-12(5-7-14)15(18,11-2-3-11)13-8-16-10-17-9-13/h4-11,18H,2-3H2,1H3
12771-68-5Relevant articles and documents
METHOD FOR PREPARATION OF 5-SUBSTITUTED PYRIMIDINES
-
, (2012/10/08)
The present invention provides a method to prepare 5-substituted pyrimidines by reacting a 5-acylpyrimidine with a suitable nucleophile to afford a 5-methanolpyrimidine, such as flurprimidol.
Patch preparations for treating plants
-
, (2008/06/13)
The following invention introduces a patch preparation for treating plants, whereas the patch preparations comprise a chemical layer composed of at least one agrochemically active compound, at least one adhesive and optionally, one or more additives. The components are dispersed in a matrix state on a substrate which are then introduced on the roots of the plant to be treated.
Aromatase Inhibition by 5-Substituted Pyrimidines and Dihydropirimidines
Taylor, Harold M.,Jones, C. David,Davenport, James D.,Hirsch, Kenneth S.,Kress, T.J.,Weaver, Dix
, p. 1359 - 1365 (2007/10/02)
The inhibition of estrogen biosynthesis has been suggested to be an effective treatment of hormone-dependent diseases, particularly breast cancer.Several series of 5-substituted pyrimidine derivatives have been synthesized and tested for their ability to inhibit the enzyme aromatase (estrogen synthetase).Compounds were evaluated in an in vitro assay that measured the inhibition of rat ovarian microsomal aromatase activity.Greatest inhibitory activity was achieved in the cases of diarylpyrimidinemethanols and diarylpyrimidinyl methanes which were substituted in the 4- and 4'-positions with electron-withdrawing substituents, particularly Cl.
