127810-78-0

Basic information

• Product Name: (2S)-N-(2-amino-4-benzyloxy-5-methoxybenzoyl)pyrrolidine-2-carbaldehyde diethyl dithioacetal
• Synonyms: (2S)-N-(2-amino-4-benzyloxy-5-methoxybenzoyl)pyrrolidine-2-carbaldehyde diethyl dithioacetal
• CAS NO: 127810-78-0
• Molecular Weight: 460.662
• Mol File: 127810-78-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2S)-N-(2-amino-4-benzyloxy-5-methoxybenzoyl)pyrrolidine-2-carbaldehyde diethyl dithioacetal(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-N-(2-amino-4-benzyloxy-5-methoxybenzoyl)pyrrolidine-2-carbaldehyde diethyl dithioacetal(127810-78-0)
• EPA Substance Registry System: (2S)-N-(2-amino-4-benzyloxy-5-methoxybenzoyl)pyrrolidine-2-carbaldehyde diethyl dithioacetal(127810-78-0)

Safety Data

• Hazardous Substances Data: 127810-78-0(Hazardous Substances Data)

Upstream product

• 127810-77-9 (2S)-N-[4-benzyloxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl dithioacetal 
• 166117-58-4 1-[2-azido-4-(benzyloxy)-5-methoxybenzoyl]prolinal 
• 75-08-1 ethanethiol 
• 100-44-7 benzyl chloride 
• 1486-53-9 4-(benzyloxy)-3-methoxybenzoic acid 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 60547-92-4 4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid 
• 105089-88-1 (2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole 
• 64154-78-5 4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride 

Downstream Products

• 81307-24-6 (11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one 
• 1104078-09-2 C₂₈H₂₇N₃O₉ 
• 1041181-54-7 (11S)-10-(4-β-D-2,3,4,6-tetra-O-acetyl-galactopyranosyloxy-3-nitro-phenyl)methoxycarbonyl-11-hydroxy-7-methoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one 
• 1041181-56-9 (11S)-10-(4-β-D-galactopyranosyloxy-3-nitro-phenyl)methoxycarbonyl-11-hydroxy-7-methoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one 
• 1041181-51-4 [2-amino-N-(4-β-D-2,3,4,6-tetra-O-acetylgalactopyranosyloxy-3-nitrophenyl)methoxycarbonyl-4-benzyloxy-5-methoxy-1,4-phenylene]carbonyl (2S)-pyrrolidine-2-carboxaldehyde diethyldithioacetal 
• 127810-79-1 8-benzyl DC-81 

Relevant articles and documents

A new convenient procedure for the synthesis of pyrrolo[2,1-c][1,4] benzodiazepines

An efficient synthesis of the pyrrolo[2,1-c][1,4] (PBD) ring system based on a new cyclisation procedure is reported. The parent unsubstituted PBD (4a) and the benzyl derivative (4b) of the natural product DC-81 (4c) have been synthesized to illustrate the utility of this procedure.

Microwave enhanced reduction of nitro and azido arenes to N-arylformamides employing Zn-HCOONH4: Synthesis of 4(3H)-quinazolinones and pyrrolo[2,1-c][1,4]benzodiazepines

Microwave mediated reduction of nitro and azido arenes to N-arylformamides using Zn-HCOONH4 is described. In the absence of microwave conditions, this methodology affords amines. This protocol has been extended to the synthesis of pyrrolo[2,1-c][1,4]benzodiazepines and 4(3H)-quinazolinones.