127810-79-1

Basic information

• Product Name: 8-benzyl DC-81
• Synonyms: 8-benzyl DC-81
• CAS NO: 127810-79-1
• Molecular Weight: 336.39
• Mol File: 127810-79-1.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 8-benzyl DC-81(CAS DataBase Reference)
• NIST Chemistry Reference: 8-benzyl DC-81(127810-79-1)
• EPA Substance Registry System: 8-benzyl DC-81(127810-79-1)

Safety Data

• Hazardous Substances Data: 127810-79-1(Hazardous Substances Data)

Upstream product

• 127810-78-0 (2S)-N-(2-amino-4-benzyloxy-5-methoxybenzoyl)pyrrolidine-2-carbaldehyde diethyl dithioacetal 
• 194783-42-1 (S)-8-Benzyloxy-7,11-dimethoxy-1,2,3,10,11,11a-hexahydro-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one 
• 339291-87-1 N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 1047976-80-6 C₃₄H₃₅N₃O₁₅ 
• 100-39-0 benzyl bromide 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 121-33-5 vanillin 
• 1041181-51-4 [2-amino-N-(4-β-D-2,3,4,6-tetra-O-acetylgalactopyranosyloxy-3-nitrophenyl)methoxycarbonyl-4-benzyloxy-5-methoxy-1,4-phenylene]carbonyl (2S)-pyrrolidine-2-carboxaldehyde diethyldithioacetal 
• 1041181-54-7 (11S)-10-(4-β-D-2,3,4,6-tetra-O-acetyl-galactopyranosyloxy-3-nitro-phenyl)methoxycarbonyl-11-hydroxy-7-methoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one 
• 1016557-17-7 C₂₂H₂₅N₅O₅ 
• 127810-77-9 (2S)-N-[4-benzyloxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl dithioacetal 
• 105089-88-1 (2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 

Downstream Products

• 81307-24-6 (11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one 

Relevant articles and documents

A new methodology for the reductive cyclization of ω-azido carbonyl compounds mediated by tetrathiomolybdate: Application to an efficient synthesis of pyrrolo[2,1-c][1,4]benzodiazepines

The ω-azido carbonyl compounds on treatment with tetrathiomolybdate, 1 led to the formation of 5, 6 and 7 membered cyclic imines in very good yields under mild conditions. This method is applied successfully to a new efficient synthesis of 1,4-benzodiazap

Facile and efficient solid-phase synthesis of DNA-interactive pyrrolo[2,1-c] [1,4]benzodiazepines

The solid-phase synthesis of pyrrolo[2,1-c][1,4]benzodiazepines is described. Isatoic anhydrides attached to chloromethyl Wang resin are coupled with proline and the polymer-bound tricyclic compounds are reduced using very mild conditions, and successivel

NOVEL CYTOTOXIC AGENTS FOR CONJUGATION OF DRUGS TO CELL BINDING MOLECULE

Provided are cytotoxic agents, pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives, their conjugates with a cell-binding agent, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.

Chemoselective aromatic azido reduction with concomitant aliphatic azide employing Al/Gd Triflates/Nal and ESI-MS mechanistic studies

Aluminium and gadolinium inflates catalyze the chemoselective reduction of aromatic azides to the corresponding amines in combination with sodium iodide. This mild chemoselective method has been applied to the synthesis of various aryl amines, C2azido-substituted pyrrolo[2,1-c]-[1,4]benzodiazepines, and fused[2,1b]quinazolinones by an intramolecular azido reduction tandem cyclization reaction. Interestingly, this methodology selectively reduces aryl azides with enhanced yields and proceeds in shorter reaction times than previous strategies. The mechanistic aspects have been investigated and the intermediates associated with this selective transformation have been intercepted and characterized by online monitoring of the reaction by ESI-MS.