128019-40-9Relevant articles and documents
Asymmetric synthesis of optically active decahydroisoquinolines useful in HIV-1 protease inhibitor synthesis
Trova, Michael P.,McGee Jr., Kevin F.
, p. 5951 - 5954 (1995)
An efficient synthesis of amino acid ester 8 is described featuring an asymmetric aza-Diels-Alder reaction of diene 5 and chiral imine 6 which establishes the asymmetry at C-3. Hydrogenation of 7 provides 8 with the desired asymmetry at C-4a and C-8a.
Towards the synthesis of HIV-protease inhibitors. Synthesis optically pure 3-carboxyl-decahydroisoquinolines
Houpis, Ioannis N.,Molina, Audrey,Reamer, Robert A.,Lynch, Joseph E.,Volante,Reider, Paul J.
, p. 2593 - 2596 (2007/10/02)
The synthesis of optically pure decahydroisoquinoline 1, a component of HIV-protease inhibitors, was accomplished in 30-33% overall yield from the readily available optically pure monoacid 4.