188936-07-4 Usage
General Description
The chemical "(3S,4aS,8aS)-2-[(2R)-2-[(4S)-2-[3-Hydroxy-2-methylphenyl]-4,5-dihydrooxazol-4-yl]-2-hydroxyethyl]decahydroisoquinoline-3-carboxylic acid tert-butylamide" is a complex compound with a molecular structure that includes multiple functional groups and stereocenters. It is a tert-butylamide derivative of decahydroisoquinoline-3-carboxylic acid, containing a dihydrooxazol-4-yl group and a hydroxyl group. (3S,4aS,8aS)-2-[(2R)-2-[(4S)-2-[3-Hydroxy-2-methylphenyl]-4,5-dihydrooxazol-4-yl]-2-hydroxyethyl]decahydroisoquinoline-3-carboxylic acid tert-butylamide may have potential pharmaceutical applications or be used as a chemical building block in organic synthesis. The presence of a carboxylic acid group suggests it may have acidic properties, and its tert-butylamide moiety may contribute to its stability and lipophilicity. Further research and characterization of this compound are likely necessary to fully understand its properties and potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 188936-07-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,9,3 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 188936-07:
(8*1)+(7*8)+(6*8)+(5*9)+(4*3)+(3*6)+(2*0)+(1*7)=194
194 % 10 = 4
So 188936-07-4 is a valid CAS Registry Number.
InChI:InChI=1/C26H39N3O4/c1-16-19(10-7-11-22(16)30)25-27-20(15-33-25)23(31)14-29-13-18-9-6-5-8-17(18)12-21(29)24(32)28-26(2,3)4/h7,10-11,17-18,20-21,23,30-31H,5-6,8-9,12-15H2,1-4H3,(H,28,32)/t17-,18+,20-,21-,23+/m0/s1
188936-07-4Relevant articles and documents
Enantioselective Synthesis of Nelfinavir via Asymmetric Bromocyclization of Bisallylic Amide
Nagao, Yoshihiro,Hisanaga, Tatsunari,Utsumi, Takahiro,Egami, Hiromichi,Kawato, Yuji,Hamashima, Yoshitaka
, p. 7290 - 7295 (2018/07/15)
We describe a concise enantioselective synthesis of the HIV-protease inhibitor nelfinavir (1) via a new route in which the key step is construction of the central optically active 1,2-amino alcohol framework via asymmetric bromocyclization of bisallylic amide with N-bromosuccinimide in the presence of a catalytic amount of (S)-BINAP or (S)-BINAP monoxide. The remaining alkene and bromo functionalities were used to install the requisite thioether and chiral perhydroisoquinoline units, respectively.
A concise synthesis of the HIV-protease inhibitor nelfinavir via an unusual tetrahydrofuran rearrangement
Zook,Busse,Borer
, p. 7017 - 7021 (2007/10/03)
An efficient synthesis of nelfinavir 1 was developed. The synthesis features an unusual rearrangement of a 3-amidotetrahydrofuran into a functionalized oxazoline. (C) 2000 Elsevier Science Ltd.
A Practical Synthesis of Nelfinavir, an HIV-Protease Inhibitor, Using a Novel Chiral C4 Building Block: (5R,6S)-2,2-Dimethyl-5-hydroxy-l,3-dioxepan-6-ylammonium Acetate
Inaba, Takashi,Birchler, Angela G.,Yamada, Yasuki,Sagawa, Shoichi,Yokota, Katsuyuki,Ando, Koji,Uchida, Itsuo
, p. 7582 - 7583 (2007/10/03)
-