167678-46-8 Usage
Description
3-ACETOXY-2-METHYLBENZOYL CHLORIDE is an organic compound with the chemical formula C9H9ClO3. It is a light yellow oil at room temperature and is commonly used as an intermediate in the synthesis of various chemical compounds, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
3-ACETOXY-2-METHYLBENZOYL CHLORIDE is used as an intermediate for the preparation of small-sized HIV protease inhibitors. Its chemical properties make it a suitable candidate for the development of antiretroviral drugs, which are crucial in the treatment of HIV and AIDS.
As an intermediate, 3-ACETOXY-2-METHYLBENZOYL CHLORIDE plays a vital role in the synthesis of HIV protease inhibitors, which are designed to block the activity of the HIV protease enzyme. This enzyme is essential for the replication of the virus, and by inhibiting its function, the spread of the virus can be significantly reduced, thus helping to manage the progression of the disease in patients.
Check Digit Verification of cas no
The CAS Registry Mumber 167678-46-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,6,7 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 167678-46:
(8*1)+(7*6)+(6*7)+(5*6)+(4*7)+(3*8)+(2*4)+(1*6)=188
188 % 10 = 8
So 167678-46-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H9ClO3/c1-6-8(10(11)13)4-3-5-9(6)14-7(2)12/h3-5H,1-2H3
167678-46-8Relevant articles and documents
Two new benzamides: Synthesis, spectroscopic characterization, X-ray diffraction, and electronic structure analyses
K?rca, Ba?ak Ko?ar,?akmak, ?ükriye,Yakan, Hasan,Odaba?o?lu, Mustafa,Büyükgüng?r, Orhan,Kütük, Halil
, (2020)
This work includes the syntheses, molecular and electronic structure analyses of two novel secondary amide compounds 3-acetoxy-2-methyl-N-(2-methoxyphenyl)benzamide, 1 and 3-acetoxy-2-methyl-N-(3-methylphenyl)benzamide, 2. The title compounds were charact
Synthesis, characterization, antioxidant, and antibacterial activities of new 2,3-dimethoxy and 3-acetoxy-2-methyl benzamides
Yakan, Hasan,Cakmak, Sukriye,Kutuk, Halil,Yenigun, Semiha,Ozen, Tevfik
, p. 2767 - 2787 (2020)
Abstract: We performed a series of novel benzamide compounds which were synthesized starting from 2,3-dimethoxybenzoic acid or 3-acetoxy-2-methylbenzoic acid and amine derivatives. All the obtained products were purified, and the analysis of these product
Rhodium-Catalyzed Alkenylation of C-H Bonds in Aromatic Amides with Alkynes
Shibata, Kaname,Natsui, Satoko,Chatani, Naoto
supporting information, p. 2234 - 2237 (2017/05/12)
The rhodium-catalyzed alkenylation of C-H bonds of aromatic amides with alkynes is reported. A variety of functional groups, including OMe, OAc, Br, Cl, and even NO2, are applicable to this reaction to give the corresponding hydroarylation prod