128303-30-0

Basic information

• Product Name: dioxindolyl-L-alanine
• CAS NO: 128303-30-0
• Molecular Weight: 236.227
• Mol File: 128303-30-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: dioxindolyl-L-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: dioxindolyl-L-alanine(128303-30-0)
• EPA Substance Registry System: dioxindolyl-L-alanine(128303-30-0)

Safety Data

• Hazardous Substances Data: 128303-30-0(Hazardous Substances Data)

Upstream product

• 236094-74-9 2-amino-3-(2-oxoindolin-3-yl)propanoic acid 
• 6536-35-2 oxindolyl-L-alanine 
• 73-22-3 L-tryptophan 
• 13081-15-7 dioxindolyl-L-alanine 

Downstream Products

• 128303-30-0 dioxindolyl-L-alanine 
• 76604-82-5 dioxindolyl-L-alanine 

Relevant articles and documents

The Halicylindramides, Farnesoid X Receptor Antagonizing Depsipeptides from a Petrosia sp. Marine Sponge Collected in Korea

Three new structurally related depsipeptides, halicylindramides F-H (1-3), and two known halicylindramides were isolated from a Petrosia sp. marine sponge collected off the shore of Youngdeok-Gun, East Sea, Republic of Korea. Their planar structures were elucidated by extensive spectroscopic data analyses including 1D and 2D NMR data as well as MS data. The absolute configurations of halicylindramides F-H (1-3) were determined by Marfey's method in combination with Edman degradation. The absolute configurations at C-4 of the dioxyindolyl alanine (Dioia) residues of halicylindramides G (2) and H (3) were determined as 4S and 4R, respectively, based on ECD spectroscopy. The C-2 configurations of Dioia in 2 and 3 were speculated to both be 2R based on the shared biogenesis of the halicylindramides. Halicylindramides F (1), A (4), and C (5) showed human farnesoid X receptor (hFXR) antagonistic activities, but did not bind directly to hFXR.