128309-56-8

Basic information

• Product Name: 4-isopropyl-N,N-dimethylbenzenesulfonamide
• Synonyms: 4-isopropyl-N,N-dimethylbenzenesulfonamide
• CAS NO: 128309-56-8
• Molecular Weight: 227.327
• Mol File: 128309-56-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-isopropyl-N,N-dimethylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-isopropyl-N,N-dimethylbenzenesulfonamide(128309-56-8)
• EPA Substance Registry System: 4-isopropyl-N,N-dimethylbenzenesulfonamide(128309-56-8)

Safety Data

• Hazardous Substances Data: 128309-56-8(Hazardous Substances Data)

Upstream product

• 7463-22-1 N,N-Dimethyl-p-chlorobenzenesulfonamide 
• 920-39-8 isopropylmagnesium bromide 
• 98-82-8 Isopropylbenzene 
• 124-40-3 dimethyl amine 

Relevant articles and documents

Iron-Catalyzed C(sp2)-C(sp3) Cross-Coupling of Chlorobenzenesulfonamides with Alkyl Grignard Reagents: Entry to Alkylated Aromatics

Alkylated benzosulfonamides are compounds of high importance in organic synthesis, including the production of pharmaceuticals, agrochemicals, and plasticizers. We report the iron-catalyzed C(sp2)-C(sp3) cross-coupling of chlorobenzosulfonamides with alkyl Grignard reagents under mild and sustainable conditions. Electronically and sterically varied benzosulfonamides as well as challenging alkyl organometallics containing β-hydrogen afford alkylated benzosulfonamides in high to excellent yields. Sulfonamide represents the most reactive activating group for iron-catalyzed cross-coupling. The process affords alkylated benzenesulfonamides poised for medicinal chemistry applications and traceless reductive cleavage.