7463-22-1

Basic information

• Product Name: p-chloro-N,N-dimethylbenzenesulphonamide
• Synonyms: p-chloro-N,N-dimethylbenzenesulphonamide;4-Chloro-N,N-dimethylbenzenesulfonamide;N,N-Dimethyl-4-chlorobenzenesulfonamide
• CAS NO: 7463-22-1
• Molecular Formula: C₈H₁₀ClNO₂S
• Molecular Weight: 219.6885
• EINECS: 231-252-1
• Mol File: 7463-22-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 311.9°C at 760 mmHg
• Flash Point: 142.4°C
• Appearance: /
• Density: 1.316g/cm³
• Vapor Pressure: 0.000547mmHg at 25°C
• Refractive Index: 1.554
• PKA: -5.11±0.70(Predicted)
• CAS DataBase Reference: p-chloro-N,N-dimethylbenzenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: p-chloro-N,N-dimethylbenzenesulphonamide(7463-22-1)
• EPA Substance Registry System: p-chloro-N,N-dimethylbenzenesulphonamide(7463-22-1)

Safety Data

• Hazardous Substances Data: 7463-22-1(Hazardous Substances Data)

Usage

General Description

p-Chloro-N,N-dimethylbenzenesulphonamide, also known as "Chloramine T," is a chemical compound commonly used as a disinfectant and antimicrobial agent. It is a white, crystalline powder, and its chemical structure consists of a chlorinated aromatic ring linked to a sulphonamide group. Chloramine T is a versatile compound and is used in a variety of applications, including water treatment, surface disinfection, and as a disinfectant in the medical and food industries. It is known for its strong oxidizing properties, making it effective in destroying bacteria, viruses, and other microorganisms. However, because of its potential to cause skin and eye irritation, as well as being corrosive to metals, it should be handled with care and according to safety guidelines.

InChI:InChI=1/C8H10ClNO2S/c1-10(2)13(11,12)8-5-3-7(9)4-6-8/h3-6H,1-2H3

Upstream product

• 1709-59-7 4-amino-N,N-dimethylbenzenesulphonamide 
• 6333-79-5 4-chloro-N-methylbenzenesulfonamide 
• 141-52-6 sodium ethanolate 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 124-40-3 dimethyl amine 
• 108-90-7 chlorobenzene 
• 13360-57-1 dimethylamino sulfonyl chloride 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 1774-47-6 trimethylsulfoxonium iodide 
• 68-12-2 N,N-dimethyl-formamide 
• 106-54-7 p-Chlorothiophenol 
• 616-38-6 carbonic acid dimethyl ester 
• 14752-66-0 sodium p-chlorobenzenesulphinate 

Downstream Products

• 1709-59-7 4-amino-N,N-dimethylbenzenesulphonamide 
• 15020-57-2 N,N-dimethyl-4-hydroxybenzenesulfonamide 
• 210918-25-5 4-aminomethyl-benzenesulfonic acid dimethylamide 
• 25837-65-4 4-ethyl-N,N-dimethylbenzenesulfonamide 
• 33322-66-6 N,n-dimethyl-p-ethyl-benzamide 
• 7364-20-7 4-ethyl-benzoic acid methyl ester 
• 101776-60-7 4-cyclohexyl-N,N-dimethylbenzenesulfonamide 
• 128309-56-8 4-isopropyl-N,N-dimethylbenzenesulfonamide 
• 10517-63-2 N,N-dimethyl-4-phenethylbenzenesulfonamide 
• 14417-01-7 N,N-dimethylbenzenesulfonamide 

Relevant articles and documents

A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions

A general electrochemical system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et3N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an alcohol as a co-solvent.

Simple N,N-dimethyl phenylsulfonamides show potent anticonvulsant effect in two standard epilepsy models

Optimization of the previously reported benzothiazine analogue A led to the identification of compound 1, which showed anti-convulsant activity in two golden standard animal models of seizure, the MES and scPTZ models. Structure-activity relationship investigation of compound 1 revealed compounds 2, 6 and 19 as attractive anti-epileptic drug (AED) candidates with potent anticonvulsant effect in both the MES and scPTZ models. As these compounds are structurally different from existing AEDs, determination of their mechanism of actions could provide clues to understanding current therapy-resistant seizures. Moreover, these simple phenylsulfoneamide compounds could be good starting points for searching broad spectrum AEDs by such in vivo screening.

Copper-mediated S-N formation via an oxygen-activated radical process: A new synthesis method for sulfonamides

Copper-mediated direct S-N formation using readily available starting materials via an oxygen-activated radical process has been developed. This method provides a novel and direct approach for synthesis of sulfonamides under air conditions. the Partner Organisations 2014.