25837-65-4

Basic information

• Product Name: 4-ethyl-N,N-dimethylbenzenesulfonamide
• Synonyms: 4-ethyl-N,N-dimethylbenzenesulfonamide
• CAS NO: 25837-65-4
• Molecular Weight: 213.301
• Mol File: 25837-65-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-ethyl-N,N-dimethylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl-N,N-dimethylbenzenesulfonamide(25837-65-4)
• EPA Substance Registry System: 4-ethyl-N,N-dimethylbenzenesulfonamide(25837-65-4)

Safety Data

• Hazardous Substances Data: 25837-65-4(Hazardous Substances Data)

Upstream product

• 16712-69-9 p-ethylbenzenesulfonyl chloride 
• 124-40-3 dimethyl amine 
• 100-41-4 ethylbenzene 
• 7463-22-1 N,N-Dimethyl-p-chlorobenzenesulfonamide 
• 2386-64-3 ethylmagnesium chloride 
• 14062-80-7 N,N-dimethyl-4-chlorobenzamide 
• 1126-46-1 Methyl 4-chlorobenzoate 

Downstream Products

• 60000-87-5 4-acetyl-N,N-dimethylbenzenesulfonamide 
• 104622-34-6 4-(N-dichloroacetyl-glycyl)-benzenesulfonic acid dimethylamide 
• 89102-54-5 4-(2-bromoacetyl)-N,N-dimethylbenzenesulfonamide 

Relevant articles and documents

Iron-Catalyzed C(sp2)-C(sp3) Cross-Coupling of Chlorobenzenesulfonamides with Alkyl Grignard Reagents: Entry to Alkylated Aromatics

Alkylated benzosulfonamides are compounds of high importance in organic synthesis, including the production of pharmaceuticals, agrochemicals, and plasticizers. We report the iron-catalyzed C(sp2)-C(sp3) cross-coupling of chlorobenzosulfonamides with alkyl Grignard reagents under mild and sustainable conditions. Electronically and sterically varied benzosulfonamides as well as challenging alkyl organometallics containing β-hydrogen afford alkylated benzosulfonamides in high to excellent yields. Sulfonamide represents the most reactive activating group for iron-catalyzed cross-coupling. The process affords alkylated benzenesulfonamides poised for medicinal chemistry applications and traceless reductive cleavage.