128461-65-4

Basic information

• Product Name: Propanal, 3-[(4-methoxyphenyl)methoxy]-
• CAS NO: 128461-65-4
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Mol File: 128461-65-4.mol
• Article Data: 71

Chemical Properties

• CAS DataBase Reference: Propanal, 3-[(4-methoxyphenyl)methoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanal, 3-[(4-methoxyphenyl)methoxy]-(128461-65-4)
• EPA Substance Registry System: Propanal, 3-[(4-methoxyphenyl)methoxy]-(128461-65-4)

Safety Data

• Hazardous Substances Data: 128461-65-4(Hazardous Substances Data)

Upstream product

• 623-12-1 4-chloromethoxybenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 824-94-2 p-methoxybenzyl chloride 
• 2746-25-0 p-Methoxybenzyl bromide 
• 5689-71-4 2-(4-methoxy-phenyl)-[1,3]dioxane 
• 107-02-8 acrolein 
• 142860-84-2 4-(p-methoxybenzyloxy)-1,2-epoxybutane 
• 504-63-2 trimethyleneglycol 
• 142860-83-1 1-(4-methoxybenzyloxy)-3-butene 
• 135362-69-5 3-(4-methoxybenzyl)oxypropan-1-ol 

Downstream Products

• 128461-59-6 (4R,5S)-3-{(R)-2-[(S)-1-Hydroxy-3-(4-methoxy-benzyloxy)-propyl]-pent-4-enoyl}-4-methyl-5-phenyl-oxazolidin-2-one 
• 199857-44-8 (2S,5S)-5-hydroxy-7-(p-methoxybenzyloxy)-2-methyl-1-(triisopropylsiloxy)-heptan-3-one 
• 201667-72-3 methyl (2E)-5-(4-methoxybenzyloxy)-2-pentenoate 
• 217076-33-0 (E)-5-(4-Methoxy-benzyloxy)-1-[2,2,4-trimethyl-3-(2-triisopropylsilanyloxy-but-3-enyl)-cyclohex-3-enyl]-pent-1-en-3-ol 
• 220249-55-8 (3S,4R)-1-(4-methoxybenzyloxy)-4-(trifluoromethyl)hex-5-en-3-ol 
• 603994-07-6 (3R,4S)-1-(4'-methoxybenzyloxy)-4-methyl-5-hexen-3-ol 
• 220430-05-7 2-(1-hydroxy-3-p-methoxybenzyloxypropyl)acrylic acid methyl ester 
• 256440-95-6 (2R,3R,6R)-3-[1-(chloromethyl)ethenyl]-2-[(R)-1-hydroxy-3-(4-methoxyphenylmethoxy)propyl]-6-methylcyclohexanone 
• 849619-01-8 1-(4-methoxybenzyloxy)-4-methylhex-5-en-3-ol 
• 636572-75-3 (4S)-4-benzyl-3-((2S)-2-{(1R)-1-hydroxy-3-[(4-methoxybenzyl)oxy]propyl}but-3-enoyl)-1,3-oxazolidin-2-one 
• 624727-26-0 ethyl 5-[(4-methoxybenzyl)oxy]-3-oxopentanoate 
• 652986-80-6 (S)-4-Benzyl-3-{(R)-2-[(2R,4R)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-propionyl}-oxazolidin-2-one 
• 740853-06-9 (4S,5R)-5-Hydroxy-7-(4-methoxy-benzyloxy)-4-methyl-heptan-3-one 
• 804559-44-2 (+)-(3R,4R)-1-[(4-methoxybenzyl)oxy]-4-methylhex-5-en-3-ol 

Relevant articles and documents

Synthesis of tetrahydrofurans from protected β-hydroxyaldehydes: Optimization of the alcohol protecting group

As part of an effort to generalize the synthesis of substituted tetrahydrofurans from protected β-hydroxy aldehydes, a series of common alcohol protecting groups was screened for compatibility with the methodology. Employing a β-(triisopropylsilyloxy)alde

Stereoselective synthesis of (-)-pinidinone

A simple and efficient stereoselective linear approach to the total synthesis of (-)-pinidinone has been accomplished starting from propane-1,3-diol, and employing Maruoka asymmetric allylation and Grubbs' olefin cross-metathesis as the key steps. Copyright

Modular Total Synthesis of iso-Archazolids and Archazologs

Full details on the design, development, and successful implementation of suitable synthetic strategies directed toward the total synthesis of iso-archazolids and archazologs are reported. Both a biomimetic and a multistep total synthesis of iso-archazolid B, the most potent and least abundant archazolid, are described. The bioinspired conversion from archazolid B was realized by a high-yielding 1,8-Diazabicyclo[5.4.0]undec-7-ene catalyzed one-step double-bond shift. A highly stereoselective total synthesis was accomplished in 25 steps, involving a sequence of highly stereoselective aldol reactions, an efficient aldol condensation to forge two elaborate fragments, and a challenging ring-closing metathesis macrocyclization with an unusual Stewart-Grubbs catalyst. These strategies proved to be generally useful and could be successfully implemented for the preparation of three novel iso-archazolids as well as five novel archazologs, lacking the thiazole side chain. A wide variety of further archazolids and archazologs may now be targeted for exploration of the promising anticancer potential of these polyketide macrolides.

BIOCATALYTIC SYNTHESIS OF CRYPTOPHYCIN ANTICANCER AGENTS

The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.