135362-69-5

Basic information

• Product Name: 3-(4-Methoxybenzyloxy)-1-propanol
• Synonyms: 3-(4-Methoxybenzyloxy)-1-propanol;3-(4-Methoxyphenylmethoxy)-1-propanol;3-((4-Methoxybenzyl)oxy)propan-1-ol
• CAS NO: 135362-69-5
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.24294
• Mol File: 135362-69-5.mol
• Article Data: 72

Chemical Properties

• Boiling Point: 334.2±22.0 °C(Predicted)
• Appearance: /
• Density: 1.071±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Dichloromethane
• PKA: 14.87±0.10(Predicted)
• CAS DataBase Reference: 3-(4-Methoxybenzyloxy)-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Methoxybenzyloxy)-1-propanol(135362-69-5)
• EPA Substance Registry System: 3-(4-Methoxybenzyloxy)-1-propanol(135362-69-5)

Safety Data

• Hazardous Substances Data: 135362-69-5(Hazardous Substances Data)

Usage

Description

3-(4-Methoxybenzyloxy)-1-propanol, also known as 3-[(4-Methoxybenzyl)oxy]propan-1-ol, is an organic compound that serves as a crucial intermediate in the synthesis of various chemical compounds. It is characterized by its molecular structure, which includes a propanol backbone with a methoxybenzyloxy group attached to the third carbon.

Uses

Used in Pharmaceutical Industry:
3-(4-Methoxybenzyloxy)-1-propanol is used as an intermediate in the synthesis of Aflatoxin G2-d3 (A357487), also known as Labelled Aflatoxin G2. Aflatoxins are a group of highly carcinogenic mycotoxins produced as secondary metabolites by certain fungal species, such as Aspergillus flavus or Aspergillus parasiticus. These fungi can grow on a variety of foods, including peanuts, nuts, spices, and cereals, posing a significant health risk due to their hepatotoxic effects.
Used in Environmental and Food Contamination Control:
3-(4-Methoxybenzyloxy)-1-propanol plays a role in the detection and monitoring of environmental and food contaminants. Aflatoxins, which this compound is involved in synthesizing, are a major concern in the food industry due to their potential to cause severe health issues. By synthesizing labelled aflatoxins, it is possible to develop detection methods and control measures to ensure the safety and quality of the food supply.

Upstream product

• 5689-71-4 2-(4-methoxy-phenyl)-[1,3]dioxane 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 504-63-2 trimethyleneglycol 
• 824-94-2 p-methoxybenzyl chloride 
• 2746-25-0 p-Methoxybenzyl bromide 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 
• 152944-16-6 1-methoxy-4-(3-(4-methoxybenzyloxy)propoxy)benzene 
• 88023-78-3 para-methoxybenzyl chloride 
• 623-12-1 4-chloromethoxybenzene 

Downstream Products

• 128461-65-4 3-(p-methoxybenzyloxy)propanal 
• 172427-68-8 ethyl <2E>-5-(4-methoxybenzyloxy)-2-pentenoate 
• 218461-38-2 Trifluoro-methanesulfonic acid 3-(4-methoxy-benzyloxy)-propyl ester 
• 203925-44-4 Toluene-4-sulfonic acid 3-(4-methoxy-benzyloxy)-propyl ester 
• 392333-41-4 3-(4-methoxybenzyloxy)propanoic acid 
• 352557-00-7 methanesulfonic acid 3-(4-methoxy-benzyloxy)-propyl ester 
• 862995-07-1 (+)-(3R,4R)-1-[(4-methoxybenzyl)oxy]-4-methyl-3-(tert-butyldiphenylsilyloxy)-5-hexene 
• 862994-97-6 (+)-(3R,4R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(4-methoxybenzyl)oxy]-3-methylhexanal 
• 862995-08-2 (-)-(3R,4R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(4-methoxybenzyl)oxy]-3-methyl-1-hexanol 
• 804559-44-2 (+)-(3R,4R)-1-[(4-methoxybenzyl)oxy]-4-methylhex-5-en-3-ol 
• 909111-05-3 C₃₄H₅₉BO₄Si 
• 740852-89-5 (4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-4-methyl-heptan-3-one 
• 740852-91-9 (3R,4S,6R,7R)-3-(tert-Butyl-dimethyl-silanyloxy)-7-hydroxy-1,9-bis-(4-methoxy-benzyloxy)-4,6-dimethyl-nonan-5-one 
• 740853-07-0 (3R,4S,6R,7R)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-1,9-bis-(4-methoxy-benzyloxy)-4,6-dimethyl-nonan-5-one 

Relevant articles and documents

Modular Total Synthesis of iso-Archazolids and Archazologs

Full details on the design, development, and successful implementation of suitable synthetic strategies directed toward the total synthesis of iso-archazolids and archazologs are reported. Both a biomimetic and a multistep total synthesis of iso-archazolid B, the most potent and least abundant archazolid, are described. The bioinspired conversion from archazolid B was realized by a high-yielding 1,8-Diazabicyclo[5.4.0]undec-7-ene catalyzed one-step double-bond shift. A highly stereoselective total synthesis was accomplished in 25 steps, involving a sequence of highly stereoselective aldol reactions, an efficient aldol condensation to forge two elaborate fragments, and a challenging ring-closing metathesis macrocyclization with an unusual Stewart-Grubbs catalyst. These strategies proved to be generally useful and could be successfully implemented for the preparation of three novel iso-archazolids as well as five novel archazologs, lacking the thiazole side chain. A wide variety of further archazolids and archazologs may now be targeted for exploration of the promising anticancer potential of these polyketide macrolides.

Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation

Monosubstituted ureas are important scaffolds in organic chemistry. They appear in various biologically active compounds and serve as versatile precursors in synthesis. Monosubstituted ureas were originally prepared using toxic and hazardous phosgene equivalents. Modern methods include transamidation of urea and nucleophilic addition to cyanate salts, both of which suffer from a narrow substrate scope due to the need for a strong acid and prolonged reaction times. We hereby report that ammonium chloride can promote the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeds rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it is compatible with other nucleophiles, acid-labile moieties, and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatography.

BIOCATALYTIC SYNTHESIS OF CRYPTOPHYCIN ANTICANCER AGENTS

The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.