128542-75-6

Basic information

• Product Name: (S)-2-BroMoMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (S)-2-BroMoMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;(S)-N-Boc-2-(broMoMethyl)pyrrolidine;(2S)-1-Boc-2-(bromomethyl)pyrrolidine
• CAS NO: 128542-75-6
• Molecular Formula: C₁₀H₁₈BrNO₂
• Molecular Weight: 264.15942
• Mol File: 128542-75-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (S)-2-BroMoMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-BroMoMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester(128542-75-6)
• EPA Substance Registry System: (S)-2-BroMoMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester(128542-75-6)

Safety Data

• Hazardous Substances Data: 128542-75-6(Hazardous Substances Data)

Usage

General Description

(S)-2-BromoMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C11H20BrNO2. It is a versatile intermediate used in the synthesis of pharmaceuticals and other organic compounds. (S)-2-BroMoMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is often used as a building block for the preparation of pyrrolidine-based drugs, such as antiviral and antihypertensive medications. Its tert-butyl ester group makes it a convenient precursor for various organic reactions, and its bromomethyl moiety allows for further functionalization. Overall, (S)-2-BromoMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is an important compound with various applications in organic synthesis and pharmaceutical chemistry.

Upstream product

• 132482-09-8 tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 86661-32-7 (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 147-85-3 L-proline 
• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 

Downstream Products

• 73236-85-8 (S)-2-<(acetylthio)methyl>-1-<(tert-butyloxy)carbonyl>pyrrolidine 
• 188625-66-3 (S)-2-(mercaptomethyl)-1-<(tert-butyloxy)carbonyl>pyrrolidine 
• 914490-60-1 2-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1108183-71-6 (S)-1-(1-(Pyrrolidin-2-ylmethyl)-1H-indazol-5-yl)-4-(4-(trifluoromethyl)phenyl)pyridin-2(1H)-one hydrochloride 
• 1173157-17-9 C₃₄H₄₀N₄O₄ 
• 1173157-76-0 (S)-tert-butyl 2-((7-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)methyl)pyrrolidine-1-carboxylate 
• 204137-96-2 (S)-tert-butyl 2-{[4-(trifluoromethyl)phenyl]sulfanylmethyl}-pyrrolidine-1-carboxylate 
• 1190207-25-0 (S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine 
• 1352662-96-4 adamantan-1-yl-((S)-1-{2-[(dicyclohexylphosphino)methyl]pyrrolidin-1-yl})-methanone 
• 1352662-97-5 (S)-1-{2-[(diphenylphosphino)methyl]pyrrolidin-1-yl}-2,2,2-triphenylethanone 
• 1352662-99-7 (S)-1-{2-[(di-tert-butylphosphino)methyl]pyrrolidin-1-yl}-2,2,2-triphenylethanone 
• 1352663-01-4 (S)-1-{2-[(dicyclohexylphosphino)methyl]pyrrolidin-1-yl}-2,2,2-triphenylethanone 
• 1352663-05-8 (S)-N-(adamantan-1-yl)-2-[(dicyclohexylphosphino)methyl]pyrrolidine-1-carboxamide 
• 1352663-07-0 (S)-2-[(di-tert-butylphosphino)methyl]-N-mesitylpyrrolidine-1-carboxamide 

Relevant articles and documents

Prolinamides of Aminouracils, Organocatalyst Modifiable by Complementary Modules

We report the synthesis and evaluation of prolinamide organocatalysts that incorporate aminouracils. The features of these catalysts are enhanced NH acidity of the amide because of the electron-withdrawing nature of the heterocycle, an additional hydrogen-bond donor at the α or β positions of this functional group (using 6-aminouracil or 5,6-diaminouracil respectively), and it can be recovered due to its low solubility and used again without decreasing the enantioselectivity. A unique feature of these systems is the self-assembly capability with complementary modules by Watson–Crick interactions. These supramolecular adducts behave differently from the catalyst alone, some of them have lower performance but others improve the selectivity of the product. Therefore, this approach avoids the synthesis of many catalysts.

Sequential deprotectionecyclisation reaction: Stereoselective synthesis of azabicyclic β-enamino ester derivatives and (-) indolizidine 209D

This paper describes a new strategy for the stereoselective synthesis of pyrrolizidine and indolizidine based enamino esters and their acyl derivatives from L-proline. The key reaction in this process involves deprotection followed by ring closure of cyclic N-Boc amino-β-ketoesters. Also, the synthesis of 5R,9R- (-)-indolizidine 209D has been accomplished using this protocol.

QUINOLINE AND QUINOXALINE DERIVATIVES AS INHIBITORS OF KINASE ENZYMATIC ACTIVITY

Compounds of formula (IA) or (IB), are inhibitors of aurora kinase activity: Formula (IA), (IB) wherein -L1Y1-[CH2]z- is a linker radical wherein Y1, L1 and z are as defined in the claims; R6 is C1-C4alkoxy, hydrogen or halo; W represents a bond, -CH2-, -O-, -S-, -S(=O)2-, or -NR5- where R5 is hydrogen or C1-C4 alkyl; Q is =N-, =CH- or =C(X1)- wherein X1 is cyano, cyclopropyl or halo; linker radicals L2 are as defined in the claims; R is a radical of formula (X) or (Y): wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroaryl(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and D is a monocyclic heterocyclic ring of 5 or 6 ring atoms.