128676-85-7 Usage
General Description
2-Chloro-3-iodoquinoline is a chemical compound with the molecular formula C9H5ClIN. It is a quinoline derivative with a chlorine atom and an iodine atom attached to the quinoline ring. 2-chloro-3-iodoquinoline is used in the field of organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential anti-bacterial and anti-cancer properties. Additionally, it has been utilized in the development of novel materials and dyes due to its unique chemical structure. Overall, 2-chloro-3-iodoquinoline is a versatile compound with a wide range of potential applications in different fields.
Check Digit Verification of cas no
The CAS Registry Mumber 128676-85-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,6,7 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 128676-85:
(8*1)+(7*2)+(6*8)+(5*6)+(4*7)+(3*6)+(2*8)+(1*5)=167
167 % 10 = 7
So 128676-85-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H5ClIN/c10-9-7(11)5-6-3-1-2-4-8(6)12-9/h1-5H
128676-85-7Relevant articles and documents
Synthesis of pyrido[2′,1′:2,3]imidazo[4,5-b]quinoline and pyrido[1′,2′:1,2]imidazo[4,5-b]quinoline and their benzo and aza analogs via tandem catalysis
Loones, Kristof T.J.,Maes, Bert U.W.,Dommisse, Roger A.
, p. 8954 - 8961 (2007)
In this paper we report regioselective tandem metal-catalyzed aminations on dihaloquinolines (2-chloro-3-iodoquinoline and 2,3-dibromoquinoline) with amino(benzo)(di)azines. Eight new heterocyclic scaffolds of the dipyridoimidazole type could be synthesized. By controlling the reaction temperature selective C-2 intermolecular Pd-catalyzed amination on 2,3-dibromoquinoline with amino(benzo)(di)azines can be achieved.
Synthesis of an indole containing KDR kinase inhibitor by tandem Sonogashira coupling-5-endo-dig-cyclization as a key step
Palimkar, Sanjay S.,More, Vijaykumar S.,Kumar, P. Harish,Srinivasan, Kumar V.
, p. 12786 - 12790 (2008/03/13)
An efficient synthesis of the potent KDR kinase inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indol-2-yl]quinoline-2-(1H)-one using a Sonogashira coupling-5-endo-dig-cyclization strategy is described.
Method of treating cancer
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, (2008/06/13)
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