128676-94-8

Basic information

• Product Name: 2-CHLOROQUINOLIN-3-OL
• Synonyms: 2-CHLOROQUINOLIN-3-OL;2-Chloro-3-hydroxyquinoline;3-Quinolinol, 2-chloro-
• CAS NO: 128676-94-8
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.6
• Mol File: 128676-94-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: >210℃
• Boiling Point: 315.201 °C at 760 mmHg
• Flash Point: 144.428 °C
• Appearance: /
• Density: 1.412
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.58±0.40(Predicted)
• CAS DataBase Reference: 2-CHLOROQUINOLIN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROQUINOLIN-3-OL(128676-94-8)
• EPA Substance Registry System: 2-CHLOROQUINOLIN-3-OL(128676-94-8)

Safety Data

• Hazardous Substances Data: 128676-94-8(Hazardous Substances Data)

Usage

General Description

2-CHLOROQUINOLIN-3-OL, also known as 2-chloro-3-hydroxyquinoline, is a chemical compound with a molecular formula C9H6ClNO. It is a derivative of quinoline, containing a chlorine atom and a hydroxyl group attached to the third and second carbon atoms, respectively. 2-CHLOROQUINOLIN-3-OL has been investigated for its potential use as an antimalarial agent, as well as for its antibacterial and antiviral properties. Its structure and chemical properties make it a promising candidate for the development of new pharmaceutical drugs targeting various infectious diseases. Additionally, 2-CHLOROQUINOLIN-3-OL has been studied for its potential use in chemical synthesis and in the development of new materials.

Upstream product

• 862249-68-1 2-chloro-3-lithioquinoline 
• 612-62-4 2-Chloroquinoline 
• 128676-84-6 (2-chloroquinolin-3-yl)boronic acid 

Downstream Products

• 26386-86-7 3-hydroxyquinolin-2(1H)-one 
• 856900-25-9 2-chloro-3-methoxymethoxy-quinoline 
• 847547-91-5 2-chloro-3-hydroxyquinoline-4-carboxylic acid 
• 1243531-74-9 C₂₂H₂₃ClN₂O₂ 

Relevant articles and documents

Enantioselective, intermolecular [2+2] photocycloaddition reactions of 3-acetoxyquinolone: Total synthesis of (-)-pinolinone

The natural product (-)-pinolinone was synthesised via a concise route (six steps, 17% overall yield) from 3-acetoxyquinolone, employing an enantioselective intermolecular [2+2] photocycloaddition as the key step. The Royal Society of Chemistry 2014.

THERAPEUTIC COMPOUNDS

no abstract published

A new approach to 3-hydroxyquinoline-2-carboxylic acid

Quinoline-2-carboxylic acid derivatives cap the N-terminal of several natural cyclic peptides with antitumoral activity. A new and convenient route for the preparation of 3-hydroxyquinoline-2-carboxylic acid is discussed. The preparation of the title compound is accomplished by a four-step procedure from 3-hydroxyquinoline via MOM protection of the hydroxyl group, followed by a 1,2-addition of methyllithium to the quinoline ring with concomitant oxidation, and, finally, a two-step oxidation procedure for the transformation of the methyl group to the carboxylic acid along with removal of the MOM group. Furthermore, different attempts to its preparation led to other interesting quinolines, such as 2-chloro-3-hydroxyquinoline-4-carboxylic acid and a protected 3,3′-dihydroxy-2,2′-biquinoline.