856900-25-9

Basic information

• Product Name: 2-chloro-3-(methoxymethoxy)quinoline
• Synonyms: 2-chloro-3-(methoxymethoxy)quinoline
• CAS NO: 856900-25-9
• Molecular Formula: C11H10ClNO2
• Molecular Weight: 224
• Mol File: 856900-25-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-3-(methoxymethoxy)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-(methoxymethoxy)quinoline(856900-25-9)
• EPA Substance Registry System: 2-chloro-3-(methoxymethoxy)quinoline(856900-25-9)

Safety Data

• Hazardous Substances Data: 856900-25-9(Hazardous Substances Data)

Upstream product

• 612-62-4 2-Chloroquinoline 
• 128676-94-8 3-hydroxy-2-chloroquinoline 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 847547-91-5 2-chloro-3-hydroxyquinoline-4-carboxylic acid 

Relevant articles and documents

A new approach to 3-hydroxyquinoline-2-carboxylic acid

Quinoline-2-carboxylic acid derivatives cap the N-terminal of several natural cyclic peptides with antitumoral activity. A new and convenient route for the preparation of 3-hydroxyquinoline-2-carboxylic acid is discussed. The preparation of the title compound is accomplished by a four-step procedure from 3-hydroxyquinoline via MOM protection of the hydroxyl group, followed by a 1,2-addition of methyllithium to the quinoline ring with concomitant oxidation, and, finally, a two-step oxidation procedure for the transformation of the methyl group to the carboxylic acid along with removal of the MOM group. Furthermore, different attempts to its preparation led to other interesting quinolines, such as 2-chloro-3-hydroxyquinoline-4-carboxylic acid and a protected 3,3′-dihydroxy-2,2′-biquinoline.