128691-92-9

Basic information

• Product Name: Acetamide, 2,2,2-trifluoro-N-(4-methyl-2-nitrophenyl)-
• CAS NO: 128691-92-9
• Molecular Formula: C9H7F3N2O3
• Molecular Weight: 248.161
• Mol File: 128691-92-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, 2,2,2-trifluoro-N-(4-methyl-2-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2,2-trifluoro-N-(4-methyl-2-nitrophenyl)-(128691-92-9)
• EPA Substance Registry System: Acetamide, 2,2,2-trifluoro-N-(4-methyl-2-nitrophenyl)-(128691-92-9)

Safety Data

• Hazardous Substances Data: 128691-92-9(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 407-25-0 trifluoroacetic anhydride 
• 89-62-3 4-methyl-2-nitroaniline 
• 350-96-9 2,2,2-trifluoro-N-(4-methylphenyl)acetamide 

Downstream Products

• 949928-16-9 4-{[(4-Methyl-2-nitrophenyl)-(2,2,2-trifluoroacetyl)amino]methyl}-benzoic acid methyl ester 
• 4600-08-2 4,N-dimethyl-2-nitroaniline 
• 2078-09-3 4-methyl-2-nitro-N-propylaniline 
• 22019-66-5 4-methyl-2-nitro-N-benzylaniline 
• 128691-96-3 N-(2-Amino-4-methyl-phenyl)-2,2,2-trifluoro-acetamide 

Relevant articles and documents

PIII/PV=O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles

An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes into azaheterocycles through sequential intermolecular reductive C?N cross coupling with boronic acids, followed by intramolecular cyclization. This method enables the rapid construction of azaheterocycles from readily available building blocks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.

Synthesis of 1-Trifluoroacetyl-3-dialkylaminomethyl-5-monosubstituted Benzimidazoline-2-thiones using Trifluoroacetic Acid as an Acylating Agent

1-Trifluoroacetyl-3-dialkylaminomethyl-5-monosubstituted benzimidazoline-2-thiones have been synthesized from p-substituted anilines which were acetylated with trifluoroacetic acid.The trifluoroacetanilides were nitrated, reduced and cyclised with carbon