4600-08-2

Basic information

• Product Name: Methyl-(4-Methyl-2-nitro-phenyl)-aMine
• Synonyms: Methyl-(4-Methyl-2-nitro-phenyl)-aMine;N,4-DiMethyl-2-nitroaniline
• CAS NO: 4600-08-2
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.1772
• EINECS: -0
• Mol File: 4600-08-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 292.6°Cat760mmHg
• Flash Point: 130.8°C
• Appearance: /
• Density: 1.212g/cm³
• Vapor Pressure: 0.00181mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: Methyl-(4-Methyl-2-nitro-phenyl)-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-(4-Methyl-2-nitro-phenyl)-aMine(4600-08-2)
• EPA Substance Registry System: Methyl-(4-Methyl-2-nitro-phenyl)-aMine(4600-08-2)

Safety Data

• Hazardous Substances Data: 4600-08-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H10N2O2/c1-6-3-4-7(9-2)8(5-6)10(11)12/h3-5,9H,1-2H3

Upstream product

• 612-45-3 4-methyl-2-nitroacetanilide 
• 623-08-5 N-methyl-p-toluidine 
• 19871-42-2 toluene-4-sulfonic acid-(4,N-dimethyl-2-nitro-anilide) 
• 64-17-5 ethanol 
• 610-39-9 3,4-Dinitrotoluene 
• 74-89-5 methylamine 
• 5326-34-1 4-Bromo-3-nitrotoluene 
• 67-56-1 methanol 
• 89-62-3 4-methyl-2-nitroaniline 
• 74-88-4 methyl iodide 
• 23042-30-0 N-methyl-N-(4-tolyl)nitramine 
• 7418-35-1 N-methyl-2-nitro-4-methylacetanilide 
• 128691-92-9 4-methyl-2-nitrotrifluoroacetanilide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 51422-10-7 N,4-dimethyl-2,6-dinitroaniline 
• 62323-65-3 4,N-dimethyl-2,6,N-trinitro-aniline 
• 39513-19-4 2-amino-4-methyl-N-methylaminobenzene 
• 423755-05-9 2-(2-chloro-5-nitro-phenyl)-1,5-dimethyl-1H-benzoimidazole 
• 423755-04-8 4-chloro-3-(1,5-dimethyl-1H-benzoimidazol-2-yl)-phenylamine 
• 690231-89-1 2-chloro-N-(5-methyl-2-methylamino-phenyl)-5-nitro-benzamide 
• 5618-84-8 7,10-dimethyl-10H-benzo[g]pteridine-2,4-dione 
• 24780-84-5 1,2,5-Trimethyl-Benzimidazol 
• 113242-94-7 4,N-dimethyl-2,6-dinitro-N-nitroso-aniline 
• 10394-35-1 1,5-dimethylbenzimidazole 
• 149530-79-0 5-methylbenzimidazoline-2-thione 
• 39860-12-3 2-Amino-1,5-dimethyl-benzimidazol 

Relevant articles and documents

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

Amino Azaxylylenes Photogenerated from o-Amido Imines: Photoassisted Access to Complex Spiro-Poly-Heterocycles

Upon irradiation, cyclic imines containing o-amido groups are shown to produce reactive intermediates, amino azaxylylenes, which undergo intramolecular cycloadditions to tethered unsaturated pendants to yield complex N,O-heterocycles having an additional spiro-connected nitrogen heterocyclic moiety. Modular assembly of the photoprecursors allows expeditious increase of the complexity of the target poly-heterocyclic scaffolds with a minimal number of experimentally simple reaction steps. The photocyclization and subsequent postphotochemical transformations are accompanied by an increase of Lovering's fsp3 factor, thus producing unprecedented three-dimensional molecular architectures, and offering extended sampling of chemical space. Rings in three dimensions: Cyclic imines containing an o-amido group undergo excited-state intramolecular proton transfer to generate amino azaxylylenes. The amino azaxylylenes undergo intramolecular cycloadditions to tethered unsaturated pendants to yield complex heterocyclic three-dimensional molecular architectures.

Synthesis and SAR of 2-arylbenzoxazoles, benzothiazoles and benzimidazoles as inhibitors of lysophosphatidic acid acyltransferase-β

2-Arylbenzoxazoles, benzothiazoles and benzimidazoles were identified as new classes of potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-β (LPAAT-β). Effects of selected inhibitors on proliferation of tumor cells in vitro were investigated.