1287731-51-4

Basic information

• Product Name: (2S,3R)-(+)-methyl 2-methyl-3-[(S)-(4-methylphenylsulfinamido)]-3-phenylpropanoate
• Synonyms: (2S,3R)-(+)-methyl 2-methyl-3-[(S)-(4-methylphenylsulfinamido)]-3-phenylpropanoate
• CAS NO: 1287731-51-4
• Molecular Weight: 331.436
• Mol File: 1287731-51-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3R)-(+)-methyl 2-methyl-3-[(S)-(4-methylphenylsulfinamido)]-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-(+)-methyl 2-methyl-3-[(S)-(4-methylphenylsulfinamido)]-3-phenylpropanoate(1287731-51-4)
• EPA Substance Registry System: (2S,3R)-(+)-methyl 2-methyl-3-[(S)-(4-methylphenylsulfinamido)]-3-phenylpropanoate(1287731-51-4)

Safety Data

• Hazardous Substances Data: 1287731-51-4(Hazardous Substances Data)

Upstream product

• 158009-86-0 (S_S,3R)-(+)-methyl 3-[N-(p-toluenesulfinyl)amino]-3-(phenyl)propanoate 
• 74-88-4 methyl iodide 

Downstream Products

• 1287731-67-2 (2S,3R)-(+)-4-N-[(S)-(p-toluenesulfinyl)]amino-3-methyl-4-phenylbutan-2-one 
• 1287731-73-0 (2S,3R)-(+)-N,2-dimethyl-3-[(S)-(4-methylphenylsulfinamido)]-3-phenylpropanamide 
• 1287731-68-3 (2S,3R)-(+)-2-methyl-3-[(S)-(4-methylphenylsulfinamido)]-1-butyl-3-phenylpropan-1-one 
• 1287731-69-4 (2S,3R)-(+)-2-methyl-3-[(S)-(4-methylphenylsulfinamido)]-1,3-diphenylpropan-1-one 

Relevant articles and documents

Asymmetric synthesis of anti-α-substituted β-amino ketones from sulfinimines

Previously unknown, enantiopure, β-amino ketones were prepared in modest yield by addition of lithium reagents to N-sulfinyl anti-α- substituted β-amino Weinreb amides. Grignard reagents failed to add to these Weinreb amides in contrast to the syn-α-substituted isomers which did. The anti-α-substituted β-amino Weinreb amides were prepared by addition of LiN(OMe)Me to the corresponding N-sulfinyl anti-α-substituted β-amino esters because α-alkylation of N-sulfinyl β-amino Weinreb amide enolates resulted in poor diastereoselectivities.