128885-78-9

Basic information

• Product Name: nitro-4 benzoate de tridesoxy-2,3,6 O-((dihydroxy-5,12 dioxo-6,11 methyl-1 tetrahydro-3,4,6,11 1H-anthra<2,3-c>pyrannyl-3-(1S,3S)) methyl)-1 trifluoroacetamido-3 L-arabino-hexopyrannose
• CAS NO: 128885-78-9
• Molecular Weight: 714.606
• Mol File: 128885-78-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: nitro-4 benzoate de tridesoxy-2,3,6 O-((dihydroxy-5,12 dioxo-6,11 methyl-1 tetrahydro-3,4,6,11 1H-anthra<2,3-c>pyrannyl-3-(1S,3S)) methyl)-1 trifluoroacetamido-3 L-arabino-hexopyrannose(CAS DataBase Reference)
• NIST Chemistry Reference: nitro-4 benzoate de tridesoxy-2,3,6 O-((dihydroxy-5,12 dioxo-6,11 methyl-1 tetrahydro-3,4,6,11 1H-anthra<2,3-c>pyrannyl-3-(1S,3S)) methyl)-1 trifluoroacetamido-3 L-arabino-hexopyrannose(128885-78-9)
• EPA Substance Registry System: nitro-4 benzoate de tridesoxy-2,3,6 O-((dihydroxy-5,12 dioxo-6,11 methyl-1 tetrahydro-3,4,6,11 1H-anthra<2,3-c>pyrannyl-3-(1S,3S)) methyl)-1 trifluoroacetamido-3 L-arabino-hexopyrannose(128885-78-9)

Safety Data

• Hazardous Substances Data: 128885-78-9(Hazardous Substances Data)

Upstream product

• 111301-38-3 Acetic acid 4-acetoxy-2-(1-bromo-ethyl)-3-((S)-2,3-diacetoxy-propyl)-9,10-dioxo-9,10-dihydro-anthracen-1-yl ester 
• 111301-48-5 (S)-diacetate de (diacetoxy-2,3 propyl)-2 ethyl-3 dioxo-9,10 dihydro-9,10 anthracenediyle-1,4 
• 111301-42-9 (-)-(S)-<(dimethyl-2,2 dioxolanne-1,3 yl-4) methyl>-2 ethyl-3 dihydroxy-1,4 anthraquinone-9,10 
• 111301-47-4 (-)-(S)-(dihydroxy-2,3 propyl)-2 ethyl-3 dihydroxy-1,4 anthraquinone-9,10 
• 23861-72-5 ethyl-2 quinizarine 
• 73891-04-0 2,3,6-tridesoxy-4-O-p-nitrobenzoyl-3-(trifluoroacetamido)-L-arabino-hex-1-enitol 
• 111407-71-7 (-)-(1S,3S)-dihydroxy-5,12 hydroxymethyl-3 methyl-1 tetrahydro-3,4,6,11 1H-anthra<2,3-c>pyrannedione-6,11 
• 111301-53-2 (+)-(1R,3S)-dihydroxy-5,12 hydroxymethyl-3 methyl-1 tetrahydro-3,4,6,11 1H-anthra<2,3-c>pyrannedione-6,11 

Relevant articles and documents

Syntheses Totales d'Oxa-9 anthracyclines

Racemic 7-hydroxy-9-oxa-anthracyclinone (5a) has been synthetised in seven steps from quinizarin (6) and its resolution achieved after glycosylation with 3,4-di-O-acetyl-2-deoxy-L-fucose.Chiral pool syntheses of (8S)-8-hydroxymethyl-9-oxa-anthracyclinone (5b) and of (8S,10R) and (8S,10S)-8-hydroxymethyl-10-methyl-9-oxa-anthracyclinones (5c and 5d) have been achieved using (R)-2,3-O-isopropylideneglyceraldehyde (12) and leucoquinizarin (13) as starting materials.Glycosylation of aglycones 5b-5d by either 3,4-di-O-acetyl-2-deoxy-L-fucose or various 3-amino-2,3,6-trideoxy-L-hexoses yielded the corresponding anthracyclines.The synthetic glycosides do not show significant cytotoxic activity at a concentration of 1 μg/ml against L 1210 cells.Keywords 9-oxa-anthracyclinone; 9-oxa-anthracycline; glycoside; chiral pool synthesis