128915-56-0 Usage
Description
N-DesMethyl Asenapine-d4 is a deuterated metabolite of Asenapine, an atypical antipsychotic drug. It is characterized by the presence of deuterium atoms, which makes it a valuable tool in scientific research and analysis. N-DesMethyl Asenapine-d4 is used to study the metabolism, pharmacokinetics, and pharmacodynamics of Asenapine, providing insights into its therapeutic effects and potential side effects.
Uses
Used in Pharmaceutical Research:
N-DesMethyl Asenapine-d4 is used as a research tool for the development and optimization of analytical methods and techniques. It aids in the identification, quantification, and monitoring of Asenapine and its metabolites in biological samples, such as blood, plasma, and urine.
Used in Drug Metabolism Studies:
N-DesMethyl Asenapine-d4 is employed as a stable isotope-labeled internal standard in mass spectrometry-based assays. It helps in the accurate measurement of Asenapine and its metabolites, ensuring the reliability and reproducibility of the results.
Used in Schizophrenia and Bipolar Disorder Treatment:
N-DesMethyl Asenapine-d4 is used as a metabolite of Asenapine, which is an atypical antipsychotic medication. It contributes to the therapeutic effects of Asenapine in the treatment of schizophrenia and acute mania associated with bipolar disorder.
Used in Drug Development:
N-DesMethyl Asenapine-d4 is utilized in the preclinical and clinical stages of drug development. It helps researchers understand the metabolic pathways, pharmacokinetics, and pharmacodynamics of Asenapine, which is crucial for the optimization of drug dosages and treatment regimens.
Check Digit Verification of cas no
The CAS Registry Mumber 128915-56-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,9,1 and 5 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 128915-56:
(8*1)+(7*2)+(6*8)+(5*9)+(4*1)+(3*5)+(2*5)+(1*6)=150
150 % 10 = 0
So 128915-56-0 is a valid CAS Registry Number.
128915-56-0Relevant articles and documents
Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
-
, (2012/07/03)
This invention provides improved processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole, asenapine. These processes allow the preparation of asenapine at industrial scale in good yields and high stereoselectivity.
Biotransformation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate in rats
d. Wildenberg,Delbressine,Kaspersen,Wagenaars,Jacobs
, p. 540 - 544 (2007/10/02)
The metabolism of trans-5-chloro-2-methyl-2,3,3a-12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate (Org 5222) labelled with [3H] or [14C] was investigated in Wistar rats. Metabolites were identified by mass spectrometry, 13C- and 1H-NMR analysis, IR spectroscopy and, wherever possible, by comparison with authentic reference compounds. The metabolites found in plasma, bile, faeces and urine revealed the processes of metabolism in which Org 5222 underwent oxidation to yield an N-oxide existing in two diastereoisomeric forms, or N-demethylation to yield a demethyl metabolite. A novel metabolite was found in bile viz. a carbamate glucuronide, formed from an intermediate carbamic acid, derived from the addition of CO2 to the demethyl metabolite.
